The gene-reduction effect of chromosomal losses detected in gastric cancers

Table 4 Multivariate analysis of 145 patients with gastric cancer for determining the significant prognostic factors

Category	Hazard ratio	95% CI	Pvalue
Model 1 (stage II and III); Genotype variables
High- vs. low-risk genotype	22.077	6.57 - 74.18	< 0.0001
Stage II vs. III	3.316	2.03 - 5.42	< 0.0001
Vein invasion, no vs. yes	0.440	0.23 - 0848	0.014
Age	1.001	0.98 - 1.03	0.957
Sex	0.852	0.44 - 1.67	0.640
Model 2 (stage II and III); No genotype variables
Stage II vs. III	4.310	2.60 - 7.13	< 0.0001
Growth pattern,	0.581	0.38 - 0.90	0.014
Sex	2.079	1.02 - 4.24	0.044
Age	0.989	0.97 - 1.02	0.370
Model 3 (stage II); Genotype variables
High- vs. low-risk genotype	15.42	1.71 - 139.5	0.015
Model 4 (stage II); No genotype variables
Tumor size	0.050	0.01 - 0.65	0.022
Histological type	0.167	0.04 - 0.79	0.024
Model 5 (stage III); Genotype variables
High- vs. low-risk genotype	19.69	4.38 - 88.53	< 0.0001
Tumor size	1.22	1.02 - 1.46	0.028
Model 6 (stage III); No genotype variables
Vein invasion, no vs. yes	0.30	0.13 - 0.70	0.006

Hazard ratios were estimated in a multivariate analysis using a stepwise procedure. A variable in the model was entered when it was a significant independent factor (P < 0.05). Hazard ratios less than 1.00 represent a decreased risk of death, whereas hazard ratios greater than 1.00 represent an increased risk of death.
CI, confidence interval.