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Table 2 The gene density, highly expressed genes, and LOH level on individual chromosomes estimated in stomach cancerous and noncancerous tissues

From: The gene-reduction effect of chromosomal losses detected in gastric cancers

 

No. of genes per a 1-Mb segment*

Top 100 highly expressed genes

(No. of transcripts per gene)*

Level of LOH (%)§

   

Baseline

(n = 15)

Low

(n = 65)

High

(n = 50)

Cancer-associated chromosomes

     

3

4.9

3 (76)

1 (7)

18 (28)

28 (56)

4

3.6

5 (53)

2 (13)

12 (18)

33 (66)

5

4.4

4 (44)

0 (0)

14 (22)

37 (74)

8

4.1

3 (32)

0 (0)

9 (14)

21 (42)

9

5.2

4 (60)

1 (7)

15 (23)

34 (68)

13

2.7

2 (121)

4 (27)

16 (25)

37 (74)

17

13.4

5 (42)

2 (13)

32 (49)

43 (86)

18

3.2

0 (0)

1 (7)

18 (28)

36 (72)

Mean values

4.8

3.3 (54)

   

Other chromosomes

     

1

7.7

8 (47)

   

2

4.7

9 (132)

   

6

5.8

7 (39)

   

7

5.2

6 (45)

   

10

5.0

2 (37)

   

11

8.9

9 (85)

   

12

7.3

10 (62)

   

14

5.3

6 (43)

   

15

5.3

2 (90)

   

16

8.6

3 (34)

   

19

19.8

8 (61)

   

20

8.3

2 (76)

   

21

5.1

1 (268)

   

22

8.4

1 (55)

   

Mean values

6.9

5.3 (69)

   
  1. *The number of transcripts of 17,723 genes was analyzed using the previously published data [21].
  2. §The details are described in the material and methods section.