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Figure 2 | BMC Gastroenterology

Figure 2

From: Life-threatening hypersplenism due to idiopathic portal hypertension in early childhood: case report and review of the literature

Figure 2

Immunohistochemical analysis of liver and spleen at splenectomy. There is strong staining for eNOS especially in the endothelium of the spleen of the IPH patient (A). In contrast, there is no detectable eNOS expression in the liver of the patient (not shown), in the spleen of a patient with liver cirrhosis (B) and in a healthy control (C). There is a strong expression of VCAM-1 in the spleen of our patient (D), whereas the expression is not restricted to endothelial cells but also found on stromal cells of myeloid origin. VCAM-1 staining is negative in hepatic tissue of our patient (not shown) and there was also no staining in splenic tissue of a patient with liver cirrhosis (E) and in healthy spleens obtained after trauma surgery (F). ET-1 is negative both in the spleen (G) and in the liver (not shown) of our patient, as well as in the splenic tissue of a patient with liver cirrhosis (H) and a healthy control (I). IPH, idiopathic portal hypertension; LC, liver cirrhosis, eNOS, endothelial nitric oxide synthase; VCAM-1, vascular endothelial adhesion molecule-1; ET-1, endothelin-1; Original magnifications ×200.

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