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Table 4 Areas under curve of ROC analysis of 25 serological markers

From: Peroxiredoxin 2: a potential biomarker for early diagnosis of Hepatitis B Virus related liver fibrosis identified by proteomic analysis of the plasma

 

State Variableb)

Test

Variablea)

Normal

Milder fibrosis

Significant fibrosis

Early cirrhosis

A

0.852

0.433

0.237

0.263

A/G

0.898

0.398

0.244

0.171

AFP

0.356

0.338

0.666

0.857

AKP

0.325

0.552

0.522

0.876

Apo AI

0.508

0.423

0.565

0.468

AST/ALT

0.818

0.148

0.247

0.692

CB

0.282

0.546

0.569

0.896

CHE

0.695

0.441

0.468

0.100

C-IV

0.136

0.470

0.799

0.894

CLU

0.290

0.527

0.738

0.453

G

0.119

0.610

0.713

0.878

HA

0.314

0.478

0.549

1.0000

HB

0.613

0.452

0.404

0.511

HP

0.329

0.601

0.603

0.537

LN

0.419

0.534

0.589

0.438

Prx II

0.216

0.872

0.500

0.577

PIIIP

0.475

0.512

0.498

0.558

PLT

0.512

0.426

0.372

0.226

Pre

0.543

0.506

0.568

0.263

PT

0.098

0.242

0.528

0.855

rGT

0.266

0.733

0.640

0.872

TB

0.3750

0.587

0.551

0.907

TC

0.688

0.424

0.294

0.637

TG

0.541

0.454

0.502

0.466

WBC

0.265

0.549

0.750

0.488

  1. a) Abbreviations used for test variables
  2. A: albumin; A/G: albumin/IgG; AFP: alpha fetal protein; AKP: alkaline phosphotase; AST: Aspartate aminotransferase; ALT: Alanine Aminotransferase; CB: Combined bilirubin; CHE: cholinesterase; C-IV: collagen type IV; CLU: clusterin; G: IgG; HA: Sodium Hyaluronate; HB: hemoglobin; HP: Haptoglobin; LN: laminin; Prx II: thioredoxin peroxidase 2; PIIIP: pre-collagen peptide type III; PLT: platelets; Pre: prealbumin; PT: prothrombin time; rGT: gama glutamyl transpeptidase; TB: total bilirubin; TC: total cholesterol; WBC: white blood cells
  3. b) The maximal AUCs for each state are shown in bold.