Skip to main content

Advertisement

Table 2 Endoscopic procedures, sedation and sedation-associated complications

From: Combined sedation with midazolam/propofol for gastrointestinal endoscopy in elderly patients

  Group A (Age 70+) Group B (Age 18-69) pvalue
total number of procedures 454(46.9%) 513(53.1%) NS
EGD 270(59.5%) 293(57.1%) NS
colonoscopy 92(20.3%) 115(22.4%) NS
ERCP 44(9.7%) 37(7.2%) NS
EUS 13(2.9%) 23(4.5%) NS
combined procedures 35(7.7%) 45(8.8%) NS
sedation, all procedures    
midazolam 4.8 ± 3.3 (2.0-54.0) 4.9 ± 2.8 (2.0-65.0) NS
propofol 77.8 ± 70.1 (10-650) 107.0 ± 75.7 (20-500) < 0.001
fentanyl (n = 128 vs. 169 patients) 0.11 ± 0.11 (0.05-1.00) 0.12 ± 0.14 (0.05-1.00) NS
sedation, procedure-specific    
EGD (n = 563)    
- midazolam 4.5 ± 0.9 (2.0-10.0) 4.7 ± 0.6 (2.0-6.0) 0.021
- propofol 59.2 ± 35.6 (10-270) 97.5 ± 60.1 (20-500) < 0.001
- fentanyl (n = 7 vs. 4 patients) - - -
colonoscopy (n = 207)    
- midazolam 4.6 ± 0.7 (3.0-5.0) 4.7 ± 0.5 (3.0-5.0) 0.045
- propofol 70.3 ± 58.7 (20-400) 75.4 ± 51.1 (30-420) NS
- fentanyl (n = 76 vs. 103 patients) 0.10 ± 0.01 (0.05-0.10) 0.13 ± 0.16 (0.05-1.00) NS
ERCP (n = 81)    
- midazolam 5.0 ± 0.9 (3.0-10.0) 5.3 ± 1.2 (3.0-10.0) NS
- propofol 204.8 ± 121.3 (20-650) 202.2 ± 117.5 (40-450) NS
- fentanyl (n = 22 vs. 29 patients) 0.10 ± 0.0 (0.10-0.10) 0.09 ± 0.02 (0.05-0.10) NS
EUS (n = 36)    
- midazolam 5.0 ± 0.0 (5.0-5.0) 4.9 ± 0.7 (3.0-7.0) NS
- propofol 70.0 ± 45.6 (10-150) 133.9 ± 83.4 (40-350) 0.016
- fentanyl (n = 9 vs. 1 patient) - - -
  Group A (Age 70+) Group B (Age 18-69) p value
combined procedures (n = 80)    
- midazolam 7.8 ± 11.2 (3.0-54.0) 6.4 ± 9.0 (3.0-65.0) NS
- propofol 84.3 ± 54.6 (30-300) 157.6 ± 86.4 (30-400) < 0.001
- fentanyl (n = 23 vs. 32 patients) 0.17 ± 0.26 (0.05-1.00) 0.13 ± 0.16 (0.05-1.00) NS
sedation-associated complications    
- respiratory 4(0.9%) 1(0.2%) NS
- hemodynamic 0(0%) 2(0.4%) NS
- agitation 1(0.2%) 6(1.2%) NS
- procedure-associated mortality 0(0%) 0(0%) NS
- 28 day mortality 13(2.9%) 5(1.0%) 0.030