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Table 2 Genes downregulated in the control CF intestine as compared to control WT, and upregulated by lubiprostone treatment of CF mice.

From: Lubiprostone ameliorates the cystic fibrosis mouse intestinal phenotype

CF WT+L CF+L Symbol Name Function/Process
0.01 0.4 0.11 Slc5a12 solute carrier family 5 (sodium/glucose cotransporter), member 12 Na-monocarboxylate transporter
0.05 0.4 0.33 Cyp4a10 cytochrome P450, family 4, subfamily a, polypeptide 10 20-HETE synthesis
0.08 0.9 0.46 Pck1 phosphoenolpyruvate carboxykinase 1, cytosolic Glucose metabolism
0.12 0.6 1.1 Pdk4 pyruvate dehydrogenase kinase, isoenzyme 4 Glucose metabolism
0.15 1.3 0.53 Fbp1 fructose bisphosphatase 1 Glucose metabolism
0.21 1.2 2.14 Hmgcs2 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 Ketogenesis
0.21 1.1 1.74 Acot2 acyl-CoA thioesterase 2 Fatty acid metabolism
0.25 1.1 0.93 Slc13a2 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2 Na-dicarboxylate transporter
0.25 1.1 1.33 Sgk1 serum/glucocorticoid regulated kinase 1 Regulation of electrolyte transport
0.33 1.6 1.32 Akr1b7 aldo-keto reductase family 1, member B7 PGF2a synthesis
0.33 1.1 2.15 Angptl4 angiopoietin-like 4 Lipid metabolism
  1. Genes whose expression level in the CF control intestine were ≥ 3-fold less than WT control and were upregulated ≥ 3-fold by lubiprostone in CF mice. Expression values are data from the GCOS analysis relative to WT control levels. Gene names are according to the Mouse Genome Informatics website http://www.informatics.jax.org/. +L = lubiprostone treated. Equal amounts of total RNA were pooled from 7-10 mice in each group and were used to interrogate the Affymetrix Mouse 430 2.0 GeneChip (n = 1 per group). The full microarray dataset is deposited in NCBI's Gene Expression Omnibus and is accessible through GEO Series accession number GSE18327 http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE18327.