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Table 1 Genes upregulated in the control CF intestine as compared to control WT, and downregulated by lubiprostone treatment of CF mice.

From: Lubiprostone ameliorates the cystic fibrosis mouse intestinal phenotype

CF WT+L CF+L Symbol Name Function/Process
1176 1.52 365 Retnlb resistin like beta Innate immunity
112 3.11 4.5 Chi3l4 chitinase 3-like 4 Innate immunity
51 0.52 8.7 Pla2g4c phospholipase A2, group IVC (cytosolic, calcium- independent) Inflammation, eicosanoid metabolism
42 0.76 3.4 Mcpt1 mast cell protease 1 Innate immunity, mast cell
23 1.32 2.8 Spna1 spectrin alpha 1 Erythrocyte cytoskeleton
18 0.23 1.3 Gsdmc2 gasdermin C2 Growth, differentiation, apoptosis
16 0.76 1.4 Mcpt2 mast cell protease 2 Innate immunity, mast cell marker
14 1.15 2.1 Mcpt9 mast cell protease 9 Innate immunity, mast cell
12 1.32 3.7 B3galt5 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 5 Sialyl Lewis-a synthesis
11 4.92 2.1 Ube2l6 ubiquitin-conjugating enzyme E2L 6 Innate immunity, ISG15- ubiquitination
8.6 1.00 1.2 Capn13 calpain 13 Growth, differentiation, apoptosis
8.0 0.23 1.4 Gsdmc4 gasdermin C4 Growth, differentiation, apoptosis
7.0 0.27 1.3 Gsdmc gasdermin C Growth, differentiation, apoptosis
4.9 0.44 1.4 Cpa3 carboxypeptidase A3, mast cell Innate immunity, mast cell marker
4.0 0.76 0.2 Fcer1a Fc receptor, IgE, high affinity I, alpha polypeptide Innate immunity, mast cell marker
3.7 1.15 1.4 Egln3 EGL nine homolog 3 (C. elegans) Prolyl hydroxylation of HIF
3.5 1.62 1 (none) single chain antibody ScFv Immunoglobulin heavy chain, immunity
3.2 0.56 0.5 Scd2 stearoyl-Coenzyme A desaturase 2 Unsaturated fatty acid synthesis
  1. Genes whose expression level in the CF control intestine were ≥ 3-fold greater than WT control and were downregulated ≥ 3-fold by lubiprostone in CF mice. Expression values are data from the GCOS analysis relative to WT control levels. When there were multiple probe sets for a particular gene the values were averaged. Gene names are according to the Mouse Genome Informatics website http://www.informatics.jax.org/. +L = lubiprostone treated. Equal amounts of total RNA were pooled from 7-10 mice in each group and were used to interrogate the Affymetrix Mouse 430 2.0 GeneChip (n = 1 per group). The full microarray dataset is deposited in NCBI's Gene Expression Omnibus and is accessible through GEO Series accession number GSE18327 http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE18327.