Figure 3
From: Lubiprostone ameliorates the cystic fibrosis mouse intestinal phenotype
Effect of lubiprostone treatment on mucus accumulation in the small intestine as measured by crypt lumen width in WT and CF mice. Crypt widths of Carnoy's fixed, PAS/AB stained sections were used as an estimate of mucus accumulation. A. Frequency distribution of crypt widths in WT control and lubiprostone (+Lubi) treated mice. B. Frequency distribution of crypt widths in CF control and lubiprostone (+Lubi) treated mice. C. Summary of crypt widths in control (Con) and lubiprostone (Lubi) treated WT and CF mice. Horizontal bars represent the group means. (8 WT control, 5 WT + lubiprostone, 6 CF control, 5 CF + lubiprostone; *: P < 0.00001 CF control vs. WT control; + P = 0.00004 CF +Lubi vs. CF control)