Psychological stress and coeliac disease in childhood: a cohort study

BMC Gastroenterology

Table 2 Psychological stress at age 2.5 years and risk of future coeliac disease (CD).

	Crude odds ratios (OR) for coeliac disease diagnosed after age 2.5
	n*	nwith CD	OR	95% CI	P
Serious life event at age 2.5 §					0.64
No serious life event	6603	18	reference
A Serious life event	2119	7	1.21	0.43-3.05
Parenting stress at age 2.5 §					1.00
Non-exposed	8202	25	reference
Exposed	442	1	0.74	0.01-4.56
Parental worries at age 2.5 §					0.64
Non-exposed	8082	25	reference
Exposed	438	0	0.00	0.00-2.34
Composite measure at age 2.5 §
Non-exposed	5837	18	reference
Exposed in one domain	2232	5	0.73	0.21-2.03	0.64
High stress in the family	300	1	1.08	0.03-6.89	0.61

*Number of parents answering the questionnaire questions referring to serious life event, parenting stress and parental worries, respectively. Due to internal attrition the numbers of reference individual vary between the different analyses.
§For definition of serious life event, parenting stress, parenting worries and the composite measure for stress, see text.
CI = Confidence interval according to exact test. P-values were calculated using Fisher's exact test.

ISSN: 1471-230X