From: Comparison of ELF, FibroTest and FibroScan for the non-invasive assessment of liver fibrosis
Test | Diagnosis | Fibrosis Stage | Cut-off | Sensitivity | Specificity | PPV | NPV | Positive LR | Negative LR |
---|---|---|---|---|---|---|---|---|---|
FibroTest | All patients [7] | F ≥ 2 | 0.32 | 0.57 | 0.60 | 0.74 | 0.42 | 1.43 | 0.71 |
 |  | F ≥ 3 | 0.59 | 0.39 | 0.88 | 0.71 | 0.67 | 3.33 | 0.69 |
 |  | F = 4 | 0.73 | 0.64 | 0.90 | 0.54 | 0.93 | 6.68 | 0.40 |
 | HCV only [7] | F ≥ 2 | 0.32 | 0.81 | 0.60 | 0.84 | 0.55 | 2.02 | 0.32 |
 |  | F ≥ 3 | 0.59 | 0.65 | 0.79 | 0.73 | 0.71 | 3.07 | 0.45 |
 |  | F = 4 | 0.73 | 0.67 | 0.81 | 0.54 | 0.88 | 3.60 | 0.41 |
 | PBC only [7] | F ≥ 2 | 0.32 | 0.30 | 0.75 | 0.75 | 0.30 | 1.20 | 0.93 |
 |  | F ≥ 3 | 0.59 | 0.08 | 1.00 | 1.00 | 0.56 | invalid | 0.92 |
 |  | F = 4 | 0.73 | 0.00 | 0.96 | 0.00 | 0.96 | 0.00 | 1.04 |
ELF | F ≥ 2 | * 9.78 | 0.78 | 0.80 | 0.88 | 0.65 | 3.88 | 0.28 | |
 |  | F ≥ 3 | * 10.22 | 0.74 | 0.70 | 0.64 | 0.79 | 2.45 | 0.37 |
 |  | F = 4 | * 10.31 | 0.91 | 0.62 | 0.29 | 0.98 | 2.39 | 0.15 |
 | HCV only [9] | F ≥ 2 | 9.78 | 0.85 | 0.80 | 0.92 | 0.67 | 4.23 | 0.19 |
 |  | F ≥ 3 | 10.22 | 0.82 | 0.74 | 0.74 | 0.82 | 3.13 | 0.24 |
 |  | F = 4 | 10.31 | 0.89 | 0.63 | 0.44 | 0.94 | 2.40 | 0.18 |
 | PBC only [22] | F ≥ 2 | 9.69 | 0.65 | 0.75 | 0.87 | 0.46 | 2.60 | 0.47 |
 |  | F ≥ 3 | 9.71 | 0.62 | 0.53 | 0.53 | 0.62 | 1.32 | 0.72 |
 |  | F = 4 | 9.89 | 1.00 | 0.52 | 0.07 | 1.00 | 2.01 | 0.00 |
TE | F ≥ 2 | * 7.20 kPa | 0.64 | 0.76 | 0.85 | 0.50 | 2.71 | 0.47 | |
 |  | F ≥ 3 | * 12.50 kPa | 0.50 | 0.87 | 0.74 | 0.70 | 3.80 | 0.58 |
 |  | F = 4 | * 17.60 kPa | 0.82 | 0.91 | 0.64 | 0.96 | 9.00 | 0.20 |
 | HCV only [33] | F ≥ 2 | 7.10 kPa | 0.79 | 0.50 | 0.79 | 0.50 | 1.58 | 0.42 |
 |  | F ≥ 3 | 9.50 kPa | 0.67 | 0.79 | 0.71 | 0.75 | 3.17 | 0.42 |
 |  | F = 4 | 12.50 kPa | 0.78 | 0.84 | 0.64 | 0.91 | 4.86 | 0.27 |
 | PBC only [34] | F ≥ 2 | 7.30 kPa | 0.39 | 1.00 | 1.00 | 0.31 | invalid | 0.61 |
 |  | F ≥ 3 | 9.80 kPa | 0.25 | 0.91 | 0.75 | 0.53 | 2.75 | 0.83 |
 |  | F = 4 | 17.30 kPa | 1.00 | 0.95 | 0.50 | 1.00 | 22.00 | 0.00 |