Figure 3
From: TNF-α induced endothelial MAdCAM-1 expression is regulated by exogenous, not endogenous nitric oxide
Effect of NOS inhibitors on MAdCAM-1 in SVEC. Cells were pretreated with vehicle, L-NAME or 1400ω with indicated concentrations and then exposed to TNF-α (20 ng/ml) stimulation in the continued presence of the NOS inhibitor. NOS inhibitors themselves did not induce MAdCAM-1 expression nor did they increase MAdCAM-1 in TNF-α treated cells. Similar results were obtained in 3 separate experiments.