|
Patient (1)
|
Initial viral load (log copies/ml)
|
% blocking production
|
Half-life(2) of free virions (hours)
|
Half-life of infected cells (days)
|
|---|
| | |
During 10 MU qd
|
After reduction to 3 MU qd
| |
minimal and maximal estimates (3)
|
|---|
|
1-A
|
6.9
|
98.4
| |
2.3
|
8.7–8.8
|
|
1-B
|
6.9
|
99.9
| |
2.5
|
3.0–3.0
|
|
1-C
|
6.7
|
99.5
| |
2.2
|
1.7–1.7
|
|
1-D
|
6.1
|
86.9
| |
1.9
|
7.8–9.0
|
|
1-E
|
5.8
|
99.5
| |
5.3
|
4.4–4.5
|
|
1-F
|
6.4
|
98.5
| |
6.4
|
3.2–3.2
|
|
1-G
|
7.0
|
95.1
| |
1.8
|
6.1–6.4
|
|
1-H
|
7.1
|
99.8
| |
1.7
|
1.1–1.1
|
|
1-I
|
7.4
|
98.9
| |
3.3
|
4.9–4.9
|
|
Group 1(4) mean (std)
|
6.7 (0.5)
|
97.4 % (0.04)
| |
3.0 hours (1.7)
|
4.5–4.7 days (2.6–2.8)
|
|
2-A
|
7.3
|
93.0
|
62.5
|
1.8
|
4.8–7.7
|
|
2-C
|
6.8
|
98.1
|
78.5
|
3.3
|
0.9–1.2
|
|
2-E
|
6.7
|
93.8
|
86.0
|
3.3
|
7.1–8.2
|
|
2-F
|
6.5
|
99.6
|
95.2
|
1.9
|
1.0–1.0
|
|
2-G
|
7.2
|
97.8
|
85.0
|
3.3
|
4.0–4.7
|
|
2-H
|
7.3
|
95.5
|
27.8
|
3.9
|
1.2–4.7
|
|
2-I
|
6.1
|
98.1
|
88.0
|
1.1
|
11.8–13.5
|
|
2-J
|
7.1
|
99.9
|
98.0
|
1.6
|
3.4–3.4
|
|
2-K
|
7.1
|
71.4
|
25.2
|
2.1
|
2.6–2.7
|
|
2-L
|
6.3
|
99.6
|
99.6
|
6.9
|
2.2–2.3
|
|
2-M
|
7.4
|
93.0
|
81.1
|
2.1
|
12.0–14.8
|
|
2-N
|
6.8
|
92.4
|
33.2
|
3.6
|
2.5–7.7
|
|
Group 2(4) mean (std)
|
6.9 (0.4)
|
94.3% (0.08)
|
69.1% (**) (26.6)
|
2.9 hours (1.6)
|
4.4–6.7 days (3.9–4.6)
|
- 1) Fitting was not done for: patients 2-B (non-detectable at day 2 on), 2-D (Null-response), 2-O (missing data and rebound). 2) For group 1 half-life of free virions is only a maximal estimate because only samples from 0, 8 and 24 hours were available. 3) Minimal and maximal estimates of the half-life of infected cells was estimated assuming Η = 1 and Η = 0 respectively in Eq 2. 4) No statistically significant differences in any parameter between the two groups. **) Statistically significant (p < 0.002) difference in percentage blocking production before and after dose reduction in group 2.
