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Table 2 Results of non-linear fitting of viral dynamics

From: Changes in anti-viral effectiveness of interferon after dose reduction in chronic hepatitis c patients: a case control study

Patient (1) Initial viral load (log copies/ml) % blocking production Half-life(2) of free virions (hours) Half-life of infected cells (days)
   During 10 MU qd After reduction to 3 MU qd   minimal and maximal estimates (3)
1-A 6.9 98.4   2.3 8.7–8.8
1-B 6.9 99.9   2.5 3.0–3.0
1-C 6.7 99.5   2.2 1.7–1.7
1-D 6.1 86.9   1.9 7.8–9.0
1-E 5.8 99.5   5.3 4.4–4.5
1-F 6.4 98.5   6.4 3.2–3.2
1-G 7.0 95.1   1.8 6.1–6.4
1-H 7.1 99.8   1.7 1.1–1.1
1-I 7.4 98.9   3.3 4.9–4.9
Group 1(4) mean (std) 6.7 (0.5) 97.4 % (0.04)   3.0 hours (1.7) 4.5–4.7 days (2.6–2.8)
2-A 7.3 93.0 62.5 1.8 4.8–7.7
2-C 6.8 98.1 78.5 3.3 0.9–1.2
2-E 6.7 93.8 86.0 3.3 7.1–8.2
2-F 6.5 99.6 95.2 1.9 1.0–1.0
2-G 7.2 97.8 85.0 3.3 4.0–4.7
2-H 7.3 95.5 27.8 3.9 1.2–4.7
2-I 6.1 98.1 88.0 1.1 11.8–13.5
2-J 7.1 99.9 98.0 1.6 3.4–3.4
2-K 7.1 71.4 25.2 2.1 2.6–2.7
2-L 6.3 99.6 99.6 6.9 2.2–2.3
2-M 7.4 93.0 81.1 2.1 12.0–14.8
2-N 6.8 92.4 33.2 3.6 2.5–7.7
Group 2(4) mean (std) 6.9 (0.4) 94.3% (0.08) 69.1% (**) (26.6) 2.9 hours (1.6) 4.4–6.7 days (3.9–4.6)
  1. 1) Fitting was not done for: patients 2-B (non-detectable at day 2 on), 2-D (Null-response), 2-O (missing data and rebound). 2) For group 1 half-life of free virions is only a maximal estimate because only samples from 0, 8 and 24 hours were available. 3) Minimal and maximal estimates of the half-life of infected cells was estimated assuming Η = 1 and Η = 0 respectively in Eq 2. 4) No statistically significant differences in any parameter between the two groups. **) Statistically significant (p < 0.002) difference in percentage blocking production before and after dose reduction in group 2.