Figure 3a. Interferon efficacy in blocking production (%) is displayed for group 1 and group 2 (logarithmic scale). For the patients that received a dose reduction after 3 days of treatment (group 2), both the efficacy for the initial, 10 MU INTERFERON daily period, is displayed as well as the reduced efficacy after the dose reduction to 3 MU daily. Note that the initial interferon efficacy between group 1 and 2 does not differ. After the dose reduction the interferon efficacy is reduced in 11/12 patients in group 2 (connected black dots).Figure 3b. The slopes of the second phase decline (days-1) is represented per patient (black squares) for both groups. No differences between both groups could be observed in this study.