Intestinal disorders

Section edited by Peter Lakatos

This section concerns all clinical and basic science aspects of intestinal disorders including but not limited to: prevention, diagnosis and management, as well as related molecular genetics and pathophysiology.

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  1. Research article

    Circulating cathelicidin levels correlate with mucosal disease activity in ulcerative colitis, risk of intestinal stricture in Crohn’s disease, and clinical prognosis in inflammatory bowel disease

    Cathelicidin (LL-37) is an antimicrobial peptide known to be associated with various autoimmune diseases. We attempt to determine if cathelicidin can accurately reflect IBD disease activity. We hypothesize tha...

    Diana Hoang-Ngoc Tran, Jiani Wang, Christina Ha, Wendy Ho, S. Anjani Mattai, Angelos Oikonomopoulos, Guy Weiss, Precious Lacey, Michelle Cheng, Christine Shieh, Caroline C. Mussatto, Samantha Ho, Daniel Hommes and Hon Wai Koon

    BMC Gastroenterology 2017 17:63

    Published on: 12 May 2017

  2. Research article

    Lactobacillus casei DG and its postbiotic reduce the inflammatory mucosal response: an ex-vivo organ culture model of post-infectious irritable bowel syndrome

    The evidence on the role of gut microbiota in post-infectious irritable bowel syndrome (PI-IBS) is convincing. Lactobacillus spp. positively affect IBS symptoms, although the mechanisms through which probiotic...

    Debora Compare, Alba Rocco, Pietro Coccoli, Debora Angrisani, Costantino Sgamato, Barbara Iovine, Umberto Salvatore and Gerardo Nardone

    BMC Gastroenterology 2017 17:53

    Published on: 14 April 2017

  3. Research article

    Inflammatory Bowel Disease (IBD) pharmacotherapy and the risk of serious infection: a systematic review and network meta-analysis

    The magnitude of risk of serious infections due to available medical therapies of inflammatory bowel disease (IBD) remains controversial. We conducted a systematic review and network meta-analysis of the exist...

    Chelle L. Wheat, Cynthia W. Ko, Kindra Clark-Snustad, David Grembowski, Timothy A. Thornton and Beth Devine

    BMC Gastroenterology 2017 17:52

    Published on: 14 April 2017

  4. Research article

    The utility of apoptosis inhibitor of macrophages as a possible diagnostic marker in patients with Crohn’s disease

    Apoptosis inhibitor of macrophages (AIM) was initially identified as an apoptosis inhibitor that supports the survival of macrophages against various apoptosis-inducing stimuli, and AIM produced by macrophages...

    Yohei Ono, Shuji Kanmura, Yuko Morinaga, Kohei Oda, Katsuto Kawabata, Shiho Arima, Fumisato Sasaki, Yuichirou Nasu, Shiroh Tanoue, Shinichi Hashimoto, Hiroki Taguchi, Hirofumi Uto, Hirohito Tsubouchi and Akio Ido

    BMC Gastroenterology 2017 17:40

    Published on: 11 March 2017

  5. Research article

    Cytomegalovirus colitis in hospitalized inflammatory bowel disease patients in Taiwan: a referral center study

    Colitis is exacerbated in patients with concurrent cytomegalovirus (CMV) infection and inflammatory bowel disease (IBD). We assessed the prevalence and clinical features of CMV colitis in hospitalized IBD pati...

    Meng-Tzu Weng, Chien-Chih Tung, Yi-Shuan Lee, Yew-Loong Leong, Ming-Jium Shieh, Chia-Tung Shun, Cheng-Yi Wang, Jau-Min Wong and Shu-Chen Wei

    BMC Gastroenterology 2017 17:28

    Published on: 13 February 2017

  6. Research article

    Prevalence of paediatric inflammatory bowel disease in Sweden: a nationwide population-based register study

    We evaluated the impact of different case definition algorithms on the prevalence of paediatric inflammatory bowel disease (IBD), Crohn’s disease (CD) and ulcerative colitis (UC) and to compare the occurrence ...

    J. F. Ludvigsson, K. Büsch, O. Olén, J. Askling, K. E. Smedby, A. Ekbom, E. Lindberg and M. Neovius

    BMC Gastroenterology 2017 17:23

    Published on: 31 January 2017

  7. Research article

    Dietary treatment of Crohn’s disease: perceptions of families with children treated by exclusive enteral nutrition, a questionnaire survey

    Diet is strongly associated with the aetiology of Crohn’s Disease (CD) and exclusive enteral nutrition (EEN) is the primary induction treatment in paediatric CD. This study explored opinions around the use of ...

    Vaios Svolos, Konstantinos Gerasimidis, Elaine Buchanan, Lee Curtis, Vikki Garrick, Jacqueline Hay, Susan Laird, Joanna Munro, Daniel R. Gaya, Richard K. Russell and Richard Hansen

    BMC Gastroenterology 2017 17:14

    Published on: 19 January 2017

  8. Research article

    Chronic constipation diagnosis and treatment evaluation: the “CHRO.CO.DI.T.E.” study

    According to Rome criteria, chronic constipation (CC) includes functional constipation (FC) and irritable bowel syndrome with constipation (IBS-C). Some patients do not meet these criteria (No Rome Constipatio...

    Massimo Bellini, Paolo Usai-Satta, Antonio Bove, Renato Bocchini, Francesca Galeazzi, Edda Battaglia, Pietro Alduini, Elisabetta Buscarini and Gabrio Bassotti

    BMC Gastroenterology 2017 17:11

    Published on: 14 January 2017

  9. Research article

    Smoking influences the need for surgery in patients with the inflammatory bowel diseases: a systematic review and meta-analysis incorporating disease duration

    Studies examining the association between smoking and the need for surgery in patients with Crohn’s disease and ulcerative colitis have reached inconsistent conclusions. These studies often do not differentiat...

    M. Ellen Kuenzig, Sang Min Lee, Bertus Eksteen, Cynthia H. Seow, Cheryl Barnabe, Remo Panaccione and Gilaad G. Kaplan

    BMC Gastroenterology 2016 16:143

    Published on: 21 December 2016

  10. Research article

    Patients with longstanding ulcerative colitis in remission do not have more irritable bowel syndrome-like symptoms than controls

    Irritable bowel syndrome (IBS) is more common in patients with ulcerative colitis (UC) than expected. The prevalence of IBS in patients with UC with longstanding disease is not known. We investigated the preva...

    D. Lundgren, J. Rutegård, V. Eklöf, R. Palmqvist and P. Karling

    BMC Gastroenterology 2016 16:139

    Published on: 24 November 2016

  11. Research article

    Addition of Lubiprostone to polyethylene glycol(PEG) enhances the quality & efficacy of colonoscopy preparation: a randomized, double-blind, placebo controlled trial

    Adequate bowel preparation is an essential prerequisite for complete mucosal visualization during colonoscopy. Polyethylene glycol (PEG) solutions are commonly used. However the large volume of the solution is...

    Rupa Banerjee, Hrushikesh Chaudhari, Nirish Shah, Arjunan Saravanan, Manu Tandan and D. Nageshwar Reddy

    BMC Gastroenterology 2016 16:133

    Published on: 13 October 2016

  12. Research article

    The dual role of Escherichia coli in the course of ulcerative colitis

    This study examines the dual role of Escherichia coli in the course of ulcerative colitis (UC). The intestinal microbiota is considered to play an important role in UC pathogenesis, but how E. coli contributes to...

    Magdalena Pilarczyk-Zurek, Magdalena Strus, Pawel Adamski and Piotr B. Heczko

    BMC Gastroenterology 2016 16:128

    Published on: 10 October 2016

  13. Case report

    Effectiveness of cyclosporine as a treatment for steroid-resistant Cronkhite-Canada syndrome; two case reports

    Cronkhite-Canada syndrome (CCS) is a rare non-inherited disorder, characterized by gastrointestinal polyposis and ectodermal changes. The pathophysiology remains unclear. Treatment with corticosteroids is cons...

    Kohei Yamakawa, Takuya Yoshino, Kotaro Watanabe, Koichiro Kawano, Akira Kurita, Naomi Matsuzaki, Yoshiaki Yuba and Shujiro Yazumi

    BMC Gastroenterology 2016 16:123

    Published on: 6 October 2016

  14. Research article

    Cirrhosis related functionality characteristic of the fecal microbiota as revealed by a metaproteomic approach

    Intestinal microbiota operated as a whole and was closely related with human health. Previous studies had suggested close relationship between liver cirrhosis (LC) and gut microbiota.

    Xiao Wei, Shan Jiang, Yuye Chen, Xiangna Zhao, Huan Li, Weishi Lin, Boxing Li, Xuesong Wang, Jing Yuan and Yansong Sun

    BMC Gastroenterology 2016 16:121

    Published on: 4 October 2016

  15. Research article

    Male-specific association between MT-ND4 11719 A/G polymorphism and ulcerative colitis: a mitochondria-wide genetic association study

    Ulcerative colitis (UC) is a chronic inflammatory disorder of still unknown pathogenesis. Increasing evidence indicates that alterations in mitochondrial respiration and thus adenosine triphosphate (ATP) produ...

    Theresa Dankowski, Torsten Schröder, Steffen Möller, Xinhua Yu, David Ellinghaus, Florian Bär, Klaus Fellermann, Hendrik Lehnert, Stefan Schreiber, Andre Franke, Christian Sina, Saleh M. Ibrahim and Inke R. König

    BMC Gastroenterology 2016 16:118

    Published on: 3 October 2016

  16. Research article

    ‘Pre-endoscopy point of care test (Simtomax- IgA/IgG-Deamidated Gliadin Peptide) for coeliac disease in iron deficiency anaemia: diagnostic accuracy and a cost saving economic model’

    International guidelines recommend coeliac serology in iron deficiency anaemia, and duodenal biopsy for those tested positive to detect coeliac disease. However, pre-endoscopy serology is often unavailable, th...

    Michelle Shui Yee Lau, Peter D. Mooney, William L. White, Victoria Appleby, Sulleman Moreea, Ismail Haythem, Joshua E. Elias, Kiran Bundhoo, Gareth D. Corbett, Liam Wong, Her Hsin Tsai, Simon S. Cross, John M. Hebden, Sami Hoque and David S. Sanders

    BMC Gastroenterology 2016 16:115

    Published on: 15 September 2016

    The Erratum to this article has been published in BMC Gastroenterology 2016 16:122

  17. Research article

    Soluble ST2 is a sensitive clinical marker of ulcerative colitis evolution

    The ST2/IL-33 pathway has been related to ulcerative colitis (UC), and soluble ST2 (sST2), to disease severity. We tested the potential usefulness of sST2 as a predictive marker of treatment response and patie...

    David Díaz-Jiménez, Marjorie De la Fuente, Karen Dubois-Camacho, Glauben Landskron, Janitza Fuentes, Tamara Pérez, María Julieta González, Daniela Simian, Marcela A. Hermoso and Rodrigo Quera

    BMC Gastroenterology 2016 16:103

    Published on: 26 August 2016

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