Hepatobiliary and pancreatic disorders

Section edited by Emmanuel A Tsochatzis and Rakesh Tandon

This section concerns all clinical and basic science aspects of hepatobiliary and pancreatic disorders including but not limited to: prevention, diagnosis and management, as well as related molecular genetics and pathophysiology.

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  1. Research article

    First clinical experience in 14 patients treated with ADVOS: a study on feasibility, safety and efficacy of a new type of albumin dialysis

    Liver failure (LF) is associated with prolonged hospital stay, increased cost and substantial mortality. Due to the limited number of donor organs, extracorporeal liver support is suggested as an appealing con...

    Wolfgang Huber, Benedikt Henschel, Roland Schmid and Ahmed Al-Chalabi

    BMC Gastroenterology 2017 17:32

    Published on: 16 February 2017

  2. Case report

    Exceptional serological and radiological response to sorafenib in 2 patients with advanced hepatocellular carcinoma and chronic hepatitis C viral infection: case report and review of the literature

    In patients with advanced hepatocellular carcinoma (HCC), the multikinase inhibitor sorafenib is the only systemic treatment that has been shown to increase overall survival. However, similar to other tyrosine...

    Catherine Atkin, Philip Earwaker, Arvind Pallan, Shishir Shetty, Pankaj Punia and Yuk Ting Ma

    BMC Gastroenterology 2017 17:30

    Published on: 14 February 2017

  3. Research article

    Analysis of risk factors related to gastrointestinal fistula in patients with severe acute pancreatitis: a retrospective study of 344 cases in a single Chinese center

    Gastrointestinal fistula (GIF) in severe acute pancreatitis (SAP) is considered as a sparse episode and studied sporadically in the literature. There is paucity of data on the prediction of the effect on risk ...

    Zhipeng Hua, Yongjie Su, Xuefeng Huang, Kang Zhang, Zhengyu Yin, Xiaoming Wang and Pingguo Liu

    BMC Gastroenterology 2017 17:29

    Published on: 14 February 2017

  4. Research article

    Efficacy, safety and pharmacokinetics of simeprevir and TMC647055/ritonavir with or without ribavirin and JNJ-56914845 in HCV genotype 1 infection

    A Phase 2a, open-label study (NCT01724086) was conducted to assess the efficacy and safety of a once-daily, 2-direct-acting-antiviral-agent (2-DAA) combination of simeprevir + TMC647055/ritonavir ± ribavirin a...

    Stefan Bourgeois, Hans Van Vlierberghe, Christophe Moreno, Hans Orlent, Frederik Nevens, Keikawus Arastéh, Yves Horsmans, Jörn M. Schattenberg, Peter Buggisch, Sven Francque, Leen Vijgen, Thomas N. Kakuda, Eva Hoeben, Donghan Luo, An Vandebosch, Bert Jacquemyn…

    BMC Gastroenterology 2017 17:26

    Published on: 10 February 2017

  5. Research article

    Comparison of telbivudine and entecavir on the change of off- treatment eGFR after 3 years of treatment in non-cirrhotic chronic hepatitis B patients

    The change of estimated glomerular filtration rate (eGFR) with off-treatment nucleos(t)ide analogues (NA) in chronic hepatitis B patients (CHB) is unclear. This study is aimed to evaluate the off-treatment eGF...

    Yang-Sheng Lin, Shou-Chuan Shih, Horng-Yuan Wang, Ching-Chung Lin, Chen-Wang Chang and Ming-Jen Chen

    BMC Gastroenterology 2017 17:22

    Published on: 31 January 2017

  6. Case report

    A case of multicentric pancreatic mixed acinar-ductal carcinoma diagnosed by a yogurt-like cell clump flowing from the papilla of Vater

    Histological confirmation is needed when the pancreatic lesions is uncertain for neoplastic or nonneoplastic. Current case with multicentric pancreatic carcinomas showing indefinite clinical images was success...

    Yoshihiro Kishida, Hiroyuki Matsubayashi, Keiko Sasaki, Shinsaku Honda, Sunao Uemura, Katsuhiko Uesaka, Akiko Todaka and Hiroyuki Ono

    BMC Gastroenterology 2017 17:20

    Published on: 23 January 2017

  7. Research article

    Quality of life and impact of bile reflux after retro colic retro gastric gastrojejunostomy in Whipple surgery

    Delayed gastric emptying and bile reflux are common concerns in long-term survivors after Whipple surgery. The study was designed to assess modified retro colic retro gastric gastrojejunostomy in reducing macr...

    Rohan Chaminda Siriwardana, Rajapaksha Walimuni Mudiyanselage Anuradha Lokubandara, Shivanthi Janaki De Silva Hewavisenthi, Saumya Kumuduni Liyanage, Dona Subani Priyangika Jayatunge and Chandika Anuradha Habarakada Liyanage

    BMC Gastroenterology 2017 17:19

    Published on: 21 January 2017

  8. Research article

    Health-related quality of Life in patients with chronic hepatitis C receiving Sofosbuvir-based treatment, with and without Interferon: a prospective observational study in Egypt

    The Egyptian government introduced the first directly acting antivirals (DAAs) into Egypt through the government funded National Treatment Program. As yet, there has been no investigation into the effects of t...

    Naglaa F. A. Youssef, Mohamed El Kassas, Amany Farag and Ashley Shepherd

    BMC Gastroenterology 2017 17:18

    Published on: 21 January 2017

  9. Research article

    Prophylaxis of post-ERC infectious complications in patients with biliary obstruction by adding antimicrobial agents into ERC contrast media- a single center retrospective study

    Patients with biliary obstruction are at high risk to develop septic complications after endoscopic retrograde cholangiography (ERC). We evaluated the benefits of local application of antimicrobial agents into...

    Hella Wobser, Agnetha Gunesch and Frank Klebl

    BMC Gastroenterology 2017 17:10

    Published on: 13 January 2017

  10. Research article

    High serum resistin associates with intrahepatic inflammation and necrosis: an index of disease severity for patients with chronic HBV infection

    Studies have revealed that resistin plays a role as an intrahepatic cytokine with proinflammatory activities. This study investigated the association between serum resistin and fibrosis severity and the possib...

    Zhongji Meng, Yonghong Zhang, Zhiqiang Wei, Ping Liu, Jian Kang, Yinhua Zhang, Deqiang Ma, Changzheng Ke, Yue Chen, Jie Luo and Zuojiong Gong

    BMC Gastroenterology 2017 17:6

    Published on: 7 January 2017

  11. Research article

    Comparison of risk adjustment methods in patients with liver disease using electronic medical record data

    Risk adjustment is essential for valid comparison of patients’ health outcomes or performances of health care providers. Several risk adjustment methods for liver diseases are commonly used but the optimal app...

    Yuan Xu, Ning Li, Mingshan Lu, Elijah Dixon, Robert P. Myers, Rachel J. Jolley and Hude Quan

    BMC Gastroenterology 2017 17:5

    Published on: 7 January 2017

  12. Research article

    A significant cancer burden and high mortality of intrahepatic cholangiocarcinoma in Thailand: a nationwide database study

    We aimed to examine the burden of intrahepatic cholangiocarcinoma (ICC) in Thailand and identify the prognostic factors for all-causes of death.

    Sombat Treeprasertsuk, Kittiyod Poovorawan, Ngamphol Soonthornworasiri, Roongruedee Chaiteerakij, Kessarin Thanapirom, Pisaln Mairiang, Kookwan Sawadpanich, Kanokwan Sonsiri, Varocha Mahachai and Kamthorn Phaosawasdi

    BMC Gastroenterology 2017 17:3

    Published on: 5 January 2017

  13. Case report

    Liver abscess and bacteremia caused by lactobacillus: role of probiotics? Case report and review of the literature

    Lactobacilli are non-spore forming, lactic acid producing, gram-positive rods. They are a part of the normal gastrointestinal and genitourinary microbiota and have rarely been reported to be the cause of infec...

    Muhammed Sherid, Salih Samo, Samian Sulaiman, Husein Husein, Humberto Sifuentes and Subbaramiah Sridhar

    BMC Gastroenterology 2016 16:138

    Published on: 18 November 2016

  14. Research article

    Long-term outcomes of liver transplantation in patients with hepatitis C infection are not affected by HCV positivity of a donor

    The use of HCV-positive livers for HCV-positive recipients is becoming more common. Our aim is to evaluate long-term outcomes in liver transplant recipients transplanted with HCV antibody-positive organs.

    Maria Stepanova, Mehmet Sayiner, Leyla de Avila, Zahra Younoszai, Andrei Racila and Zobair M. Younossi

    BMC Gastroenterology 2016 16:137

    Published on: 15 November 2016

  15. Research article

    The incidence, presentation, outcomes, risk of mortality and economic data of drug-induced liver injury from a national database in Thailand: a population-base study

    Toxic liver diseases are mainly caused by drug-induced liver injury (DILI). We assessed incidences and outcomes of DILI including associated factors for mortality.

    Abhasnee Sobhonslidsuk, Kittiyod Poovorawan, Ngamphol Soonthornworasiri, Wirichada Pan-ngum and Kamthorn Phaosawasdi

    BMC Gastroenterology 2016 16:135

    Published on: 28 October 2016

  16. Research article

    Usefulness of ascitic fluid lactoferrin levels in patients with liver cirrhosis

    Although elevated levels of lactoferrin provide a biomarker for inflammatory bowel diseases and colorectal cancer, the clinical significance of these elevated levels in ascitic fluid of patients with ascites c...

    Sang Soo Lee, Hyun Ju Min, Ja Yun Choi, Hyun Chin Cho, Jin Joo Kim, Jae Min Lee, Hong Jun Kim, Chang Yoon Ha, Hyun Jin Kim, Tae Hyo Kim, Jin Hyun Kim and Ok-Jae Lee

    BMC Gastroenterology 2016 16:132

    Published on: 13 October 2016

  17. Research article

    The impact of race and ethnicity on mortality and healthcare utilization in alcoholic hepatitis: a cross-sectional study

    Alcoholic Hepatitis (AH) is major source of alcohol-related mortality and health care expenditures in the United States. There is insufficient information regarding the role of race and ethnicity on healthcare...

    Folasade P. May, Vineet S. Rolston, Elliot B. Tapper, Ashwini Lakshmanan, Sammy Saab and Vinay Sundaram

    BMC Gastroenterology 2016 16:129

    Published on: 10 October 2016

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