Hepatobiliary and pancreatic disorders

Section edited by Emmanuel A Tsochatzis and Rakesh Tandon

This section concerns all clinical and basic science aspects of hepatobiliary and pancreatic disorders including but not limited to: prevention, diagnosis and management, as well as related molecular genetics and pathophysiology.

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  1. Research article

    Cholesterol esterification in plasma as a biomarker for liver function and prediction of mortality

    Advanced stages of liver cirrhosis lead to a dramatically increased mortality. For valid identification of these patients suitable biomarkers are essential. The most important biomarkers for liver function are...

    Thorsten Kaiser, Benedict Kinny-Köster, Michael Bartels, Thomas Berg, Markus Scholz, Cornelius Engelmann, Daniel Seehofer, Susen Becker, Uta Ceglarek and Joachim Thiery

    BMC Gastroenterology 2017 17:57

    Published on: 20 April 2017

  2. Research article

    Proteinuria and baseline renal function predict mortality and renal outcomes after sirolimus therapy in liver transplantation recipients

    Chronic kidney disease is a significant complication after liver transplantation (LT), but the role of pre-existing renal insufficiency and proteinuria remains unclear among LT recipients receiving sirolimus.

    Lung-Chih Li, Chien-Ning Hsu, Chih-Che Lin, Yu-Fan Cheng, Tsung-Hui Hu, Ding-Wei Chen, Chih-Hsiung Lee, Toshiaki Nakano and Chao-Long Chen

    BMC Gastroenterology 2017 17:58

    Published on: 20 April 2017

  3. Research article

    Vitamin D-related gene polymorphism predict treatment response to pegylated interferon-based therapy in Thai chronic hepatitis C patients

    Patients with chronic hepatitis C (HCV) infection have high prevalence of vitamin D deficiency. Genome-wide association study data has showed that several genetic variants within vitamin D cascade affect vitam...

    Kessarin Thanapirom, Sirinporn Suksawatamnuay, Wattana Sukeepaisarnjaroen, Pisit Tangkijvanich, Sombat Treeprasertsuk, Panarat Thaimai, Rujipat Wasitthankasem, Yong Poovorawan and Piyawat Komolmit

    BMC Gastroenterology 2017 17:54

    Published on: 17 April 2017

  4. Research article

    The inverse effect of meal intake on controlled attenuation parameter and liver stiffness as assessed by transient elastography

    Controlled attenuation parameter (CAP) and liver stiffness (LS) measured by transient elastography (TE, Fibroscan®) have been used for steatosis and fibrosis assessment. We evaluated the effect of meal intake ...

    Kanittha Ratchatasettakul, Sasivimol Rattanasiri, Kwannapa Promson, Pranee Sringam and Abhasnee Sobhonslidsuk

    BMC Gastroenterology 2017 17:50

    Published on: 13 April 2017

  5. Research article

    The relationship of serum alanine aminotransferase normal-range levels to arterial stiffness and metabolic syndrome in non-drinkers and drinkers: a Chinese community-based analysis

    Few studies have investigated the relationship between carotid-femoral pulse wave velocity (cfPWV) and serum alanine aminotransferase (ALT) normal-range levels across the world. The current analysis was design...

    Shihui Fu, Ying Lin, Leiming Luo and Ping Ye

    BMC Gastroenterology 2017 17:49

    Published on: 11 April 2017

  6. Research article

    Costs and quality of life of small-incision open cholecystectomy and laparoscopic cholecystectomy - an expertise-based randomised controlled trial

    Health care providers need solid evidence based data on cost differences between alternative surgical procedures for common surgical disorders. We aimed to compare small-incision open cholecystectomy (SIOC) an...

    Mats H. Rosenmüller, Erik Nilsson, Fredrik Lindberg, Sten-Olof Åberg and Markku M. Haapamäki

    BMC Gastroenterology 2017 17:48

    Published on: 8 April 2017

  7. Research article

    A preliminary investigation on single nucleotide polymorphism rs2287622 of bile salt export pump gene in patients with chronic hepatitis C virus infection in Hunan, China

    European researchers have underscored associations between single nucleotide polymorphism (SNP) rs2287622 of the hepatobiliary bile salt export pump (BSEP) gene and the risk of hepatitis C virus (HCV) infectio...

    Jian-Hua Lei, Xu Yang, Xin-Qiang Xiao, Zi Chen and Feng Peng

    BMC Gastroenterology 2017 17:42

    Published on: 14 March 2017

  8. Research article

    Comparison of the long-term efficacy between entecavir and tenofovir in treatment- naïve chronic hepatitis B patients

    There have been limited studies directly comparing the long-term efficacy between entecavir (ETV) and tenofovir disoproxil fumarate (TDF). This study was aimed to compare the long-term efficacy between them in...

    Ji Won Park, Kyeong Min Kwak, Sung Eun Kim, Myoung Kuk Jang, Ki Tae Suk, Dong Joon Kim, Sang Hoon Park, Myung Seok Lee, Hyoung Su Kim and Choong Kee Park

    BMC Gastroenterology 2017 17:39

    Published on: 9 March 2017

  9. Research article

    The H.O.U.S.E. classification: a novel endoscopic retrograde cholangiopancreatography (ERCP) complexity grading scale

    Endoscopic retrograde cholangiopancreatography (ERCP) is a technically challenging endoscopic procedure, harboring a wide range of complexities within every single investigation. Classifications of the complex...

    Greger Olsson, Urban Arnelo, Fredrik Swahn, Björn Törnqvist, Lars Lundell and Lars Enochsson

    BMC Gastroenterology 2017 17:38

    Published on: 9 March 2017

  10. Research article

    “Non alcoholic fatty liver disease and eNOS dysfunction in humans”

    NAFLD is associated to Insulin Resistance (IR). IR is responsible for Endothelial Dysfunction (ED) through the impairment of eNOS function. Although eNOS derangement has been demonstrated in experimental model...

    Marcello Persico, Mario Masarone, Antonio Damato, Mariateresa Ambrosio, Alessandro Federico, Valerio Rosato, Tommaso Bucci, Albino Carrizzo and Carmine Vecchione

    BMC Gastroenterology 2017 17:35

    Published on: 7 March 2017

  11. Research article

    First clinical experience in 14 patients treated with ADVOS: a study on feasibility, safety and efficacy of a new type of albumin dialysis

    Liver failure (LF) is associated with prolonged hospital stay, increased cost and substantial mortality. Due to the limited number of donor organs, extracorporeal liver support is suggested as an appealing con...

    Wolfgang Huber, Benedikt Henschel, Roland Schmid and Ahmed Al-Chalabi

    BMC Gastroenterology 2017 17:32

    Published on: 16 February 2017

  12. Case report

    Exceptional serological and radiological response to sorafenib in 2 patients with advanced hepatocellular carcinoma and chronic hepatitis C viral infection: case report and review of the literature

    In patients with advanced hepatocellular carcinoma (HCC), the multikinase inhibitor sorafenib is the only systemic treatment that has been shown to increase overall survival. However, similar to other tyrosine...

    Catherine Atkin, Philip Earwaker, Arvind Pallan, Shishir Shetty, Pankaj Punia and Yuk Ting Ma

    BMC Gastroenterology 2017 17:30

    Published on: 14 February 2017

  13. Research article

    Analysis of risk factors related to gastrointestinal fistula in patients with severe acute pancreatitis: a retrospective study of 344 cases in a single Chinese center

    Gastrointestinal fistula (GIF) in severe acute pancreatitis (SAP) is considered as a sparse episode and studied sporadically in the literature. There is paucity of data on the prediction of the effect on risk ...

    Zhipeng Hua, Yongjie Su, Xuefeng Huang, Kang Zhang, Zhengyu Yin, Xiaoming Wang and Pingguo Liu

    BMC Gastroenterology 2017 17:29

    Published on: 14 February 2017

  14. Research article

    Efficacy, safety and pharmacokinetics of simeprevir and TMC647055/ritonavir with or without ribavirin and JNJ-56914845 in HCV genotype 1 infection

    A Phase 2a, open-label study (NCT01724086) was conducted to assess the efficacy and safety of a once-daily, 2-direct-acting-antiviral-agent (2-DAA) combination of simeprevir + TMC647055/ritonavir ± ribavirin a...

    Stefan Bourgeois, Hans Van Vlierberghe, Christophe Moreno, Hans Orlent, Frederik Nevens, Keikawus Arastéh, Yves Horsmans, Jörn M. Schattenberg, Peter Buggisch, Sven Francque, Leen Vijgen, Thomas N. Kakuda, Eva Hoeben, Donghan Luo, An Vandebosch, Bert Jacquemyn…

    BMC Gastroenterology 2017 17:26

    Published on: 10 February 2017

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