Gastroesophageal disorders

Section edited by Yeong Yeh Lee and Jan Bornschein

This section concerns all clinical and basic science aspects of gastroesophageal disorders including but not limited to: prevention, diagnosis and management, as well as related molecular genetics and pathophysiology.

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  1. Research article

    FBXW7 expression is associated with prognosis and chemotherapeutic outcome in Chinese patients with gastric adenocarcinoma

    FBXW7, a component of the Skp-Cullin1-F-box, mediates target protein recognition. It is a tumor suppressor gene that plays a role in the regulation of cell cycle exit and reentry via c-Myc, c-Jun and Notch deg...

    Mao-Ran Li, Chun-Chao Zhu, Tian-Long Ling, Ye-Qian Zhang, Jia Xu, En-Hao Zhao and Gang Zhao

    BMC Gastroenterology 2017 17:60

    Published on: 2 May 2017

  2. Research article

    Real life results in using 5-ASA for maintaining mild to moderate UC patients in Japan, a multi-center study, OPTIMUM Study

    Efficacy of maintenance therapy in ulcerative colitis (UC) in the remission stage has been reported to depend on release profile or dosing regimen of oral 5-aminosalicylic acid (5-ASA) products used. Aim of th...

    Masakazu Nagahori, Shuji Kochi, Hiroyuki Hanai, Takayuki Yamamoto, Shiro Nakamura, Soji Omuro, Mamoru Watanabe and Toshifumi Hibi

    BMC Gastroenterology 2017 17:47

    Published on: 4 April 2017

  3. Research article

    Comparison of five tumor regression grading systems for gastric adenocarcinoma after neoadjuvant chemotherapy: a retrospective study of 192 cases from National Cancer Center in China

    Neoadjuvant chemotherapy has been increasingly practiced on gastric cancer (GC), and histological evaluation to predict outcome is urgent in clinical practice. There are five classic tumor regression grading (...

    Yuelu Zhu, Yongkun Sun, Shangying Hu, Yong Jiang, Jiangying Yue, Xuemin Xue, Lin Yang and Liyan Xue

    BMC Gastroenterology 2017 17:41

    Published on: 14 March 2017

  4. Case report

    A case of type 1 multiple endocrine neoplasia with esophageal stricture successfully treated with endoscopic balloon dilation and local steroid injection combined with surgical resection of gastrinomas

    In type 1 multiple endocrine neoplasia (MEN1), esophageal diseases association with excessive gastrin secretion in Zollinger-Ellison syndrome (ZES) sometimes develop. Here, we reported a case of MEN1/ZES, who ...

    Hiroyuki Matsubayashi, Noboru Kawata, Naomi Kakushima, Masaki Tanaka, Kohei Takizawa, Yoshimi Kiyozumi, Yasue Horiuchi, Keiko Sasaki, Teiichi Sugiura, Katsuhiko Uesaka and Hiroyuki Ono

    BMC Gastroenterology 2017 17:37

    Published on: 7 March 2017

  5. Research article

    High expression of Claudin-2 in esophageal carcinoma and precancerous lesions is significantly associated with the bile salt receptors VDR and TGR5

    Claudins are a family of integral membrane proteins and are components of tight junctions (TJs). Many TJ proteins are known to tighten the cell structure and maintain a barrier. Claudin-2 forms gated paracellu...

    Sohaib Abu-Farsakh, Tongtong Wu, Amy Lalonde, Jun Sun and Zhongren Zhou

    BMC Gastroenterology 2017 17:33

    Published on: 17 February 2017

  6. Research article

    Levofloxacin or Clarithromycin-based quadruple regimens: what is the best alternative as first-line treatment for Helicobacter pylori eradication in a country with high resistance rates for both antibiotics?

    Helicobacter pylori eradication rates in Portugal are declining, due to increased resistance of this bacterium to antimicrobial agents, especially Clarithromycin. Quadruple Levofloxaci...

    Diogo Branquinho, Nuno Almeida, Carlos Gregório, José Eduardo Pina Cabral, Adriano Casela, Maria Manuel Donato and Luís Tomé

    BMC Gastroenterology 2017 17:31

    Published on: 15 February 2017

  7. Research article

    Uridine stimulate laxative effect in the loperamide-induced constipation of SD rats through regulation of the mAChRs signaling pathway and mucin secretion

    Uridine (Urd), which has been reported as a major component of RNA, plays an important role in various biological process including neuroprotection, biochemical modulation and glycolysis, although its role in ...

    Ji Eun Kim, Jun Go, Ji Eun Sung, Hyun Ah Lee, Woo Bin Yun, Jin Tae Hong and Dae Youn Hwang

    BMC Gastroenterology 2017 17:21

    Published on: 26 January 2017

  8. Research article

    Triple therapy versus sequential therapy for the first-line Helicobacter pylori eradication

    The eradication rate of Helicobacter pylori (H. pylori) with triple therapy which was considered as standard first-line treatment has decreased to 70–85%. The aim of this study is to compare 7-day triple therapy ...

    Ji Young Chang, Ki-Nam Shim, Chung Hyun Tae, Ko Eun Lee, Jihyun Lee, Kang Hoon Lee, Chang Mo Moon, Seong-Eun Kim, Hye-Kyung Jung and Sung-Ae Jung

    BMC Gastroenterology 2017 17:16

    Published on: 21 January 2017

  9. Research article

    The cut-off value of tumor size and appropriate timing of follow-up for management of minimal EUS-suspected gastric gastrointestinal stromal tumors

    The detectable rate of minimal gastric GISTs has continuously increased. While the surveillance and management of GIST <2 cm have been deemed controversial or lack evidence-based approaches.  The aim of the cu...

    Zhidong Gao, Chao Wang, Qian Xue, Jingtong Wang, Zhanlong Shen, Kewei Jiang, Kai Shen, Bin Liang, Xiaodong Yang, Qiwei Xie, Shan Wang and Yingjiang Ye

    BMC Gastroenterology 2017 17:8

    Published on: 11 January 2017

  10. Research article

    Relationship of body weight with gastrointestinal motor and sensory function: studies in anorexia nervosa and obesity

    Whether gastrointestinal motor and sensory function is primary cause or secondary effect of abnormal body weight is uncertain. Moreover, studies relating continuous postprandial sensations of satiation to meas...

    Sena Bluemel, Dieter Menne, Gabriella Milos, Oliver Goetze, Michael Fried, Werner Schwizer, Mark Fox and Andreas Steingoetter

    BMC Gastroenterology 2017 17:4

    Published on: 5 January 2017

  11. Research article

    Clinical significance of UGT1A1 polymorphism and expression of ERCC1, BRCA1, TYMS, RRM1, TUBB3, STMN1 and TOP2A in gastric cancer

    Individualized therapeutic regimen is a recently intensively pursued approach for targeting diseases, in which the search for biomarkers was considered the first and most important. Thus, the goal of this stud...

    Yongkuan Cao, Guohu Zhang, Peihong Wang, Jun Zhou, Wei Gan, Yaning Song, Ling Huang, Ya Zhang, Guode Luo, Jiaqing Gong and Lin Zhang

    BMC Gastroenterology 2017 17:2

    Published on: 5 January 2017

  12. Research article

    Analyzing the influence of gastric intestinal metaplasia on gastric ulcer healing in Helicobacter pylori–infected patients without atrophic gastritis

    Gastric epithelial hyper-proliferation was reported in patients with Helicobacter pylori (H. pylori)–infected gastric mucosa with intestinal metaplasia (IM) changes. In patients with gastric ulcer (GU) and IM, th...

    Li-Wei Chen, Liang-Che Chang, Chung-Ching Hua, Bor-Jen Hsieh, Shuo-Wei Chen and Rong-Nan Chien

    BMC Gastroenterology 2017 17:1

    Published on: 3 January 2017

  13. Research article

    The prognostic influence of body mass index, resting energy expenditure and fasting blood glucose on postoperative patients with esophageal cancer

    Body mass index (BMI), resting energy expenditure (REE) and fasting blood glucose (FBG) are major preoperative assessments of patients’ nutrition and metabolic state. The relations and effects of these indices...

    Ning Wu, Yongjun Zhu, Dhruba Kadel, Liewen Pang, Gang Chen and Zhiming Chen

    BMC Gastroenterology 2016 16:142

    Published on: 21 December 2016

  14. Case report

    Malignant transformation of a gastric hyperplastic polyp in a context of Helicobacter pylori-negative autoimmune gastritis: a case report

    Gastric foveolar hyperplastic polyps (GFHPs) are common findings in clinical practice. GFHPs commonly arise in a background of chronic atrophic gastritis, including autoimmune gastritis (type A gastritis), and...

    Kenichi Yamanaka, Hiroyuki Miyatani, Yukio Yoshida, Takehiro Ishii, Shinichi Asabe, Osamu Takada, Mitsuhiro Nokubi and Hirosato Mashima

    BMC Gastroenterology 2016 16:130

    Published on: 12 October 2016

  15. Research article

    Role of vitamin D3 combined to alginates in preventing acid and oxidative injury in cultured gastric epithelial cells

    Gastric diseases are a worldwide problem in modern society, as reported in the USA, in the range of 0.5–2 episodes/year/person and an incidence of 5–100 episodes/1000/week according to seasons and age. There i...

    Francesca Uberti, Claudio Bardelli, Vera Morsanuto, Sabrina Ghirlanda and Claudio Molinari

    BMC Gastroenterology 2016 16:127

    Published on: 7 October 2016

  16. Research article

    Should every region use the same gastric cancer scanning and treatment approaches? let’s reconsider: a northeastern turkey example

    The rate for upper gastrointestinal (UGI) cancers, and especially the rate for gastric cancer, varies from country to country and from region to region within country. In Turkey, the incidence of gastric cance...

    Albayrak Fatih, Ozturk Yasin, Dursun Hakan and Albayrak Yavuz

    BMC Gastroenterology 2016 16:120

    Published on: 4 October 2016

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