Comparison of morning versus afternoon cecal intubation rates
© Wells et al; licensee BioMed Central Ltd. 2007
Received: 18 December 2006
Accepted: 08 June 2007
Published: 08 June 2007
Many factors impacting cecal intubation rates have been examined in detail; however, little information exists regarding the effect of the timing of the procedure. We sought to examine any difference in cecal intubation rates between morning and afternoon colonoscopies and identify factors contributing to a discrepancy.
Retrospective, single-center study comparing cecal intubation rates for colonoscopies performed in the morning (begun prior to 12 noon) and colonoscopies performed in the afternoon (begun after 12 noon) over an approximately 12 month period. Univariate and multivariate analyses were performed evaluating patient demographics, procedure indication(s), endoscopist, bowel preparation type and quality, and participation by a gastroenterology fellow.
6087 colonoscopies were evaluated in this study. Colonoscopies (n = 3729) performed in the morning were compared to colonoscopies performed in the afternoon (n = 2358). The crude completion rate to the cecum was 95.0% in the morning group while the completion rate to the cecum was 93.6% of the afternoon exams (p = 0.02). The morning colonoscopies had better bowel preparation quality (p < 0.001). The multivariate analyses demonstrated that gender, age, and bowel preparation quality impacted completion rates. After correcting for these factors, there was no significant difference in completion rates in the morning versus afternoon.
Uncorrected cecal intubation rates were lower in the afternoon compared to the morning in outpatients undergoing colonoscopy. Bowel preparation quality was worse in the afternoon compared with the morning. Efforts at improving afternoon bowel preparation may improve the outcome of afternoon colonoscopies.
Examination of the entire colon is necessary to detect and remove as many polyps as possible to maximize the effectiveness of colorectal cancer screening.  A number of factors such as gender, age, prior hysterectomy, body mass index and endoscopist's experience have been identified in the literature as impacting cecal intubation rates. [2–10] Additionally, age, gender, bowel preparation quality, history of constipation, body mass index and endoscopist's experience have been reported to affect procedure duration. [11, 12] Cecal intubation rates have been used as a one measure of quality of colonoscopic examination.  While any single measure of quality is imperfect, it is generally accepted that cecal intubation rates for both diagnostic and screening colonoscopies should be >90% for individuals and institutions. [13–15] However, this target is not always achieved. [1, 15, 16] While many of these factors have been studied in depth, the timing of colonoscopy (ie morning versus afternoon) has not been studied in detail. Sanaka, et al, recently reported a lower cecal intubation rate in a retrospective study of 2087 colonoscopies comparing morning and afternoon colonoscopies. They reported a statistically significant difference in cecal intubation rates between morning and afternoon exams after excluding cases limited by poor bowel preparation.  The aim of our study was to evaluate the relationship of cecal intubation rates between colonoscopies performed in the morning and afternoon and identify factors contributing to a difference in between the groups using multiple logistic regression analysis.
The Internal Review Board at our institution (Mayo Clinic, Scottsdale, AZ) approved the study. All endoscopies performed at our institution are reported in the Clinical Outcomes Research Initiative (CORI) database. Using the CORI database, we identified all outpatient colonoscopies between January 26, 2004 and January 13, 2005. The cecal intubation rates were compared for exams that began prior to 12:00 noon (AM Group) with those begun after 12:00 noon (PM Group). Only colonoscopies that were intended to reach the cecum were included. Each endoscopist determined if the cecum was successfully intubated at the time of the colonoscopy. The cecum was identified by the presence of the appendiceal orifice and the ileocecal valve. If the cecum was not reached, then the colonoscopy was deemed incomplete.
Data on patient age, patient gender, endoscopist, indication(s), type of bowel preparation, quality of bowel preparation and cecal intubation rate was extracted and analyzed. The CORI database requires the assignment of bowel preparation quality in the report as follows: "excellent," "good," "fair, adequate exam," "fair, exam compromised," or "poor." Any examinations lacking appropriate documentation of bowel preparation quality were excluded. Bowel preparations were defined as acceptable ("excellent," "good," or "fair, adequate exam") or unacceptable ("fair, exam compromised," or "poor"). All patients during this time period had been instructed by nursing staff and/or printed literature to complete their bowel preparation the evening prior to the examination. The patients at our institution are instructed to adhere to a clear liquid diet the day prior to the examination and to assume "nothing per mouth" status after midnight. The bowel preparation consists of four liters of polyethylene glycol (PEG) electrolyte solution. Over 95% of patients receive this bowel preparation at our institution. A small minority receives other bowel preparations including phopha soda bowel preparations.
Cecal intubation rates for the AM and PM groups were compared using the Chi-square statistic and 95% confidence intervals. Group comparisons for patient demographics, involvement of gastroenterology fellow, indication(s), type of bowel preparation and quality of bowel preparation were compared using the Chi-square statistic and 95% confidence intervals or the Student's t-test as appropriate for the distribution of each variable. All endoscopists performing at least 50 colonoscopies during this study were similarly examined. Multivariate logistic regression analyses were used to establish odds ratios after controlling for potentially confounding variables.
Mean Age (range)
PEG Bowel Prep
OR 1.30 (95% CI 1.04–1.62)
Acceptable Bowel Prep
OR 1.86 (95% CI 1.53 – 2.25)
Indication(s) for Examinations.
Surveillance Adenomatous Polyps
Screening/(+) Family History
Change in Bowel Habits
97 (2.6 %)
95% Confidence Interval
0.88 – 1.39
1.28 – 2.02
0.97 – 0.99
0.76 – 1.79
Acceptable Bowel Prep
4.13 – 7.14
The finding of lower unadjusted cecal intubation rates in the PM group has a number of implications. From an institutional perspective, the identification of such a discrepancy should lead to the exploration of methods to eliminate this difference. From a physician's perspective, afternoon examinations may be more challenging when bowel preparation quality is poorer and also less satisfying when the cecal intubation rate is lower. From a patient's perspective, morning examinations already seem to be preferable, in general. Our data suggest that morning examinations may be both more convenient and associated with a higher completion rate.
Adequate bowel preparation is a prerequisite for performing a quality colonoscopic examination. Generally, bowel preparations deemed "fair, exam compromised" and "poor" necessitate a repeat examination, and this is the reason for making the distinction between "acceptable" and "unacceptable" groups. Even without separating preparation quality into these two groups, significant differences are present in the categories assigned during the report between the morning and afternoon groups. This is most likely due to the patients beginning the bowel preparation twenty or more hours prior to the examination.
Physician and staff fatigue could be a factor in lower afternoon completion rates, but there is no evidence of this on multivariate analysis. If there had been no difference in any of the variables, we would have had to consider this possibility more strongly. Nevertheless, it is still possible that physician and staff fatigue is contributory, as the rating of bowel preparation quality is subjective and difficult to standardize. In our outpatient endoscopy unit 25 endoscopists practice and are routinely assigned half-day endoscopy calendars that vary between mornings and afternoons. Less than 5% of the time an individual endoscopist will perform colonoscopies in both the morning and afternoon on the same day. This practice pattern may or may not influence our results.
There are several limitations to our study. First, this data was collected retrospectively and is therefore subject to unforeseen confounding factors despite our best analysis. The CORI database includes a data entry field in which the reason for an incomplete examination should be listed. Omission of data in this field in 63% of the incomplete examination reports leaves our study without potentially corroborating information. If a high percentage of examinations suggested that the bowel preparation quality prevented the completion of the exam, then this would have been confirmatory. In the future we will consider making this field mandatory for completion of the report. Our practice patterns may not be universally applicable. For example, our patients took the bowel preparation the evening prior to the exam irrespective of the timing of colonoscopy on the following day. Additionally, other practices may have a significant number of procedures performed after a different bowel preparation regimen. The practice pattern of endoscopists rarely performing a full day of outpatient procedures may not be universally applicable, as well. Lastly, the presence or absence of diverticulosis was not examined in this study. The has been demonstrated to impact cecal intubation rates in at least one study.  For this study, that variable was not analyzed because while diverticulosis is routinely documented on the patient reports, it was not felt to be reliably documented in a searchable field.
Overall, our findings are similar to those reported by Sanaka, et al.  In both studies, cecal intubation rates were statistically lower in the afternoon and bowel preparation was statistically more impaired in the afternoon. However, there are several differences. First, age and gender were found to impact cecal intubation rates in our study which has been demonstrated in other studies. [2–10] Secondly, after correcting for the variables of gender, increasing age and impaired bowel preparation, there was no statistically difference cecal intubation rates between the morning and afternoon groups in our study. The larger number of patients in our study or differences in the patient populations or in the settings of the two studies may account for these findings.
A number of measures should be considered to address these findings. One method would be to alter the administration of the bowel preparation, particularly for afternoon exams, to consume all or a portion of the preparation on the same day of the colonoscopy. Splitting the 4L of PEG electrolyte solution into 2L consumed the evening prior to the exam and 2L consumed the morning of the exam has been shown to produce a higher quality bowel preparation compared to consuming 4L the evening prior to the procedure in one study.  Secondly, performing as many colonoscopies as possible in the morning (which would likely lead to more upper endoscopies in the afternoon) would improve completion rates based upon our data. Finally, selecting older patients for morning appointments may also improve quality. Each of these measures should be explored in a prospective fashion to formulate a strategy that optimizes bowel preparation quality.
The uncorrected cecal intubation rate at our institution is lower for afternoon examinations compared to morning examinations, and bowel preparation quality is significantly worse in the afternoon compared with the morning. Female gender, increasing age and poorer bowel preparation quality were associated with significantly lower cecal intubation rates. After adjusting for these contributing variables, no difference in cecal intubation rates was noted in this study. Prospective studies are needed to evaluate methods to improve afternoon bowel preparation quality, to reduce the number of compromised examinations and to reduce the need for repeat examinations.
The Clinical Outcomes Research Initiative (CORI) project was supported with funding from NIDDK UO1 CA 89389-01 and R33-DK61778-01. In addition, the CORI practice network has received support from the following entities to support the infrastructure of the practice-based network: AstraZeneca, Novartis, Bard International, Pentax USA, ProVation, Endosoft, GIVEN Imaging, and Ethicon. The commercial entities had no involvement in this research.
- Lieberman DA, Weiss DG, Bond JH, Ahnen DJ, Garewal H, Chejfec G, et al: Use of colonoscopy to screen asymptomatic adults for colorectal cancer. N Engl J Med. 2000, 343: 162-8. 10.1056/NEJM200007203430301.View ArticlePubMedGoogle Scholar
- Waye JD, Bashkoff E: Total Colonosocpy: is it always possible?. Gastrointest Endosc. 1991, 37: 152-4.View ArticlePubMedGoogle Scholar
- Church JM: Complete colonoscopy: how often? And if not, why?. Am J Gastroenterol. 1994, 89 (4): 556-60.PubMedGoogle Scholar
- Cirocco WC, Rusin LC: Factors that predict incomplete colonoscopy. Dis Col Rect. 1995, 38: 964-8. 10.1007/BF02049733.View ArticleGoogle Scholar
- Saunders BP, Fukumoto M, Halligan S, Jobling C, Moussa ME, Bartram CI, et al: Why is colonosocpy more difficult in women?. Gastrointest Endosc. 1996, 43: 124-6. 10.1016/S0016-5107(96)70317-6.View ArticlePubMedGoogle Scholar
- Anderson JC, Gonzalez JD, Messina CR, Pollack BJ: Factors that predict colonoscopy: thinner is not always better. Am J Gastroenterol. 2000, 95: 2784-7. 10.1111/j.1572-0241.2000.03186.x.View ArticlePubMedGoogle Scholar
- Dafnis G, Granath F, Pahlman L, Ekbom A, Blomqvist P: Patient factors influencing the completion rate in colonoscopies. Dig Liv Dis. 2005, 37: 113-8. 10.1016/j.dld.2004.09.015.View ArticleGoogle Scholar
- Chak A, Cooper GS, Blades EW, Canto M, Sivak MV: Prospective assessment of colonoscopic intubation skills in trainees. Gastrointest Endosc. 1996, 44: 54-7. 10.1016/S0016-5107(96)70229-8.View ArticlePubMedGoogle Scholar
- Wexner SD, Garbus JE, Singh JJ: A prospective analysis of 13,580 colonoscopies: reevaluation of credentialing guidelines. Surg Endosc. 2001, 15: 251-61. 10.1007/s004640080147.View ArticlePubMedGoogle Scholar
- Harewood GC: Relationship of colonscopy completion rates and endoscopist features. Dig Dis Sci. 2005, 50: 47-51. 10.1007/s10620-005-1276-y.View ArticlePubMedGoogle Scholar
- Kim WH, Cho YJ, Park JY, Min PK, Kand JK, Park IS: Factors affecting insertion time and patient discomfort during colonosocpy. Gastrointest Endosc. 2000, 52: 600-5. 10.1067/mge.2000.109802.View ArticlePubMedGoogle Scholar
- Bernstein C, Thorn M, Monsees K, Spell R, O'Connor JB: A prospective study of factors that determine cecal intubation time at colonoscopy. Gastrointest Endosc. 2005, 61: 72-5. 10.1016/S0016-5107(04)02461-7.View ArticlePubMedGoogle Scholar
- Ball JE, Osbourne J, Jowett S, Pellen M, Welfare MR: Quality improvement programme to achieve acceptable colonoscopy completion rates: prospective before and after study. BMJ. 2004, 329: 665-7. 10.1136/bmj.329.7467.665.View ArticlePubMedPubMed CentralGoogle Scholar
- Marshall JB, Barthel JS: The frequency of total colonoscopy and ileal intubation in the 1990's. Gastrointest Endosc. 1993, 39: 518-20.View ArticlePubMedGoogle Scholar
- Rex DK, Bond JH, Winawer S, Levin TR, Burt RW, Johnson DA, et al: Quality in the technical performance of colonoscopy and the continuous quality improvement process for colonoscopy: recommendations of the U.S. Multi-Society Task Force on Colorectal Cancer. Am J Gastroenterol. 2002, 97: 1296-1308. 10.1111/j.1572-0241.2002.05812.x.View ArticlePubMedGoogle Scholar
- Cotton PB, Connor P, McGee D, Jorwell P, Nickl N, Schutz S, et al: Colonoscopy: practice variation among 69 hospital-based endoscopists. Gastrointest Endosc. 2003, 57: 352-7. 10.1067/mge.2003.121.View ArticlePubMedGoogle Scholar
- Sanaka MR, Shah N, Mullen KD, Ferguson DR, Thomas C, McCullough AJ: Afternoon Colonoscopies Have Higher Failure Rates Compared to Morning Colonoscopies. Am J Gastroenterol. 2006, 101: 2726-30. 10.1111/j.1572-0241.2006.00887.x.View ArticlePubMedGoogle Scholar
- Aoun E, Abdul-Baki H, Azar C, Mourad F, Barada K, Berro Z, et al: A randomized single-blind trial of split-dose PEG-electrolyte solution without dietary restriction compared with whole dose PEG-electrolyte solution with dietary restriction for colonoscopy preparation. Gastrointest Endosc. 2005, 62: 213-8. 10.1016/S0016-5107(05)00371-8.View ArticlePubMedGoogle Scholar
- The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-230X/7/19/prepub