Most bowel cancer symptoms do not indicate colorectal cancer and polyps: a systematic review
© Adelstein et al; licensee BioMed Central Ltd. 2011
Received: 30 September 2010
Accepted: 30 May 2011
Published: 30 May 2011
Bowel symptoms are often considered an indication to perform colonoscopy to identify or rule out colorectal cancer or precancerous polyps. Investigation of bowel symptoms for this purpose is recommended by numerous clinical guidelines. However, the evidence for this practice is unclear. The objective of this study is to systematically review the evidence about the association between bowel symptoms and colorectal cancer or polyps.
We searched the literature extensively up to December 2008, using MEDLINE and EMBASE and following references. For inclusion in the review, papers from cross sectional, case control and cohort studies had to provide a 2×2 table of symptoms by diagnosis (colorectal cancer or polyps) or sufficient data from which that table could be constructed. The search procedure, quality appraisal, and data extraction was done twice, with disagreements resolved with another reviewer. Summary ROC analysis was used to assess the diagnostic performance of symptoms to detect colorectal cancer and polyps.
Colorectal cancer was associated with rectal bleeding (AUC 0.66; LR+ 1.9; LR- 0.7) and weight loss (AUC 0.67, LR+ 2.5, LR- 0.9). Neither of these symptoms was associated with the presence of polyps. There was no significant association of colorectal cancer or polyps with change in bowel habit, constipation, diarrhoea or abdominal pain. Neither the clinical setting (primary or specialist care) nor study type was associated with accuracy.
Most studies had methodological flaws. There was no consistency in the way symptoms were elicited or interpreted in the studies.
Current evidence suggests that the common practice of performing colonoscopies to identify cancers in people with bowel symptoms is warranted only for rectal bleeding and the general symptom of weight loss. Bodies preparing guidelines for clinicians and consumers to improve early detection of colorectal cancer need to take into account the limited value of symptoms.
Keywordscolorectal cancer colorectal polyps bowel symptoms rectal bleeding change in bowel habit
Adenocarcinoma of the colon and rectum is the third most common cancer and the third leading cause of death in the United Kingdom. In 2004, there were almost 40,000 new cases diagnosed, and about 16,000 deaths from colorectal cancer . The symptoms with which colorectal cancer are purported to present most commonly include alteration in bowel habit, rectal bleeding, abdominal pain and weight loss [2, 3].
Bowel symptoms occur commonly in the community and are often self limiting. There is little information available about why or when people seek medical attention for them [4, 5]. Colonoscopies to exclude colorectal cancer are done frequently for a wide range of bowel symptoms, a practice suggested by guidelines  although it is unclear which symptoms, if any, improve the diagnostic yield of cancers or polyps. The costs, both clinical and financial, of performing colonoscopies are high. To inform policy, it is therefore important to assess which symptoms, if any, are associated with cancer and precancerous polyps.
The aim of this systematic review was to assess the evidence about the association between bowel symptoms and colorectal cancer or colorectal polyps.
We conducted a comprehensive search of the health literature for all studies evaluating symptoms and colorectal cancer or polyps. The search was undertaken in December 2008 to identify relevant studies. We searched MEDLINE (1966-2008) and complete EMBASE, using a list of symptoms and diagnoses as MeSH headings; the full search strategy is given in Additional File 1. The literature selection was based initially on the paper title, and if thought relevant, followed in turn by the abstract or full paper. Foreign language papers were translated into English. The literature search and selection of papers for full review, was carried out independently on two occasions 6 months apart by one reviewer.
Further, the references included in all selected papers, as well as review articles, were assessed for possible inclusion in the systematic review. The citations for each paper identified for inclusion in the review were also checked using the cited reference component of the Web of Science database.
For inclusion in the review, papers had to provide sufficient data about both the symptom and diagnosis (colorectal cancer or polyps) and provide a 2×2 table of symptoms by diagnosis, or the data from which that table could be constructed. We did not restrict included papers to certain study types, and we have extensively explored whether study characteristics had any effect on the findings. Papers (n = 8) that did not differentiate between cancers and polyps were excluded. Only full papers were included: where a relevant conference abstract was found, the literature was searched for a more detailed description of the study. If no full paper was found, the abstract was not included (this occurred with 1 abstract) .
Data extraction and methodological assessment
Extraction of data was performed by one reviewer (BA), with the complete set of data extracted independently on two separate occasions 6 months apart. Issues of uncertainty or discrepancy between the data extraction sets were referred to a second reviewer (LI); this occurred in 50% of papers. Agreement was subsequently obtained at consensus meetings.
For each study, data about methodology, quality and population characteristics were extracted. Items assessed included the clinical setting of the study, whether all participants had at least one symptom or some were asymptomatic (population type), whether each participant could have only one or more than one symptom reported, and study design items (patient recruitment from general or specialist practice settings, prospective or retrospective data collection, year of publication, consecutive patient recruitment, study type, reference standard used), and the ease with which data could be extracted from the paper. We also assessed the prevalence of cancer in each paper. The data categories and the assumptions required to extract the data are shown in Additional File 2.
One paper described two studies, for which we combined the data . In the same paper, there were 'don't know' responses that were categorised as "present" for our analysis. This did not occur in more than 4.4% of responses.
We used colorectal cancer and polyps only as the two main outcome measures. Colorectal cancer included colon and rectal cancer, and included cancers that were confirmed by histology, as well as cancers listed as such in the papers but with no criteria given for the diagnosis. In general, papers providing information about polyps did not differentiate between polyps greater or less than 10 mm, or between different polyp histology; results are therefore for all polyps.
We have presented results for all symptoms for cancer, but for polyps and for comparisons between cancer and polyps we have included results only for those symptoms which showed a significant association for cancer.
The estimated sensitivity and specificity were used to estimate the diagnostic odds ratio (DOR (=[sensitivity/(1-sensitivity)]/[(1-specificity)/specificity]) which provides a single summary measure of test accuracy for each study. A high DOR indicates high test accuracy; a test that performs no better than chance in discriminating between diseased and non-diseased persons has a DOR of one. Summary ROC (SROC) methods were used to investigate the accuracy of symptoms for the diagnosis of colorectal cancer (or polyps); and to investigate whether study methodology, quality and population characteristics were associated with the diagnostic performance of symptoms. Preliminary exploratory analyses for each symptom were conducted using the SROC linear regression method of Moses and Littenberg . The loge(DOR) was modeled (using unweighted least squares) as a function of the underlying test positivity rate (logit (sensitivity) + logit(1-specificity)) which is a proxy for test threshold. Study and patient characteristics were fitted as covariates. Regression diagnostics were examined to identify outliers and potentially influential studies in determining the shape and position (accuracy) of the SROC curve.
Studies were further analysed using the hierarchical SROC (HSROC) model of Rutter and Gatsonis [10, 11]. This mixed model is more complex, but more rigorous that the Moses and Littenberg method because it takes separate account of the uncertainty in the estimates of sensitivity and specificity within each study, and includes random study effects for both test accuracy and positivity criterion (proxy for threshold), thereby taking account of unexplained heterogeneity between studies. The model also allows test accuracy to vary with "threshold" through the inclusion of a scale (shape) parameter fitted as a fixed effect which provides for asymmetry in the SROC. Fixed effect covariates were fitted to assess whether accuracy, positivity criterion or the shape of the SROC was associated with study or patient characteristics. Empirical Bayes estimates of model parameters were obtained using PROC NLMIXED in SAS . These parameter estimates were used to obtain summary estimates and 95% confidence intervals for sensitivity and specificity (summary operating point), and likelihood ratios. The area under the SROC curve (AUC) was computed using numerical integration. Where the summary curve was symmetric, the DOR is also reported as it is constant across all thresholds.
Covariates that showed at least very weak association (p < 0.25) with diagnostic performance in the preliminary analysis were included in the model to assess whether test accuracy, the positivity criterion and/or the shape of the SROC varied with population and study design characteristics. The chosen level for statistical significance was 5% (two sided). Where summary ROC curves being compared had the same shape, the relative DOR (RDOR) was used as the summary measure of the relative diagnostic performance, otherwise the AUC was used. Only results that were robust to the removal of an influential study are reported.
Comparison of the accuracy of each symptom for the diagnosis of colorectal cancer versus polyps was restricted to studies that provided data for both outcomes. This "paired" analysis, where the diagnosis is fitted as a covariate in the HSROC model, ensures that the comparison is not confounded by study or patient characteristics.
The fitted summary ROC curves derived from the HSROC model are displayed in ROC space, and are superimposed on the study specific estimates of sensitivity and specificity that are denoted by an ellipse. The horizontal and vertical dimensions of each ellipse are proportional to the square root of the number of non-diseased and diseased respectively. A cross is used to show the summary estimate of sensitivity and specificity. For the "paired" analyses, the two points for each study are joined by a line; points are denoted by circles that do not vary in size for the sake of clarity for these plots.
As this is a systematic review conducted on previously published papers and did not use patient level data, no approval was required.
The literature search yielded 14,121 articles, of which 248 were selected for full review. Three non-English papers were translated but only one met the inclusion criteria. We identified 62 eligible papers that provided relevant information separately for cancers and polyps [8, 13–73]. Studies were published between 1960 and 2008. Quality and study characteristics and descriptors are shown in Additional File 2.
There was a wide range of symptoms included in the papers, with many papers providing information on several symptoms: 26 separate symptoms were included, as well as 3 combinations of symptoms (for example, bleeding together with change in bowel habit). In addition, some papers provided information about descriptions of bleeding. A full list of papers, with all outcomes, and symptoms is provided in Additional File 3.
Overview of results: Symptoms association with cancer.
DOR* (95% CI*)
Sensitivity (95% CI)
LR+ (95% CI)
LR- (95% CI)
p < 0.001
Blood mixed with stool:
p < 0.001
Blood: dark red
(1.7 - 9.2)
P = 0.004
Change in bowel habit
p = 0.16
p = 0.48
p = 0.65
p = 0.12
p = 0.001
Results are presented below for the association between each symptom and cancer. Where the association was significant, results are also presented for the association between that symptom and polyps.
Forty papers provided information about the relationship between bleeding (of any type) and colorectal cancer [13–21, 23–28, 30, 32, 33, 35, 37, 41, 42, 45–47, 50, 51, 54–56, 60–66, 69, 72, 73], and 23 of these papers [13–17, 20, 21, 23, 24, 26, 28, 30, 33, 41, 42, 46, 47, 54, 56, 61, 63, 72, 73] also provided information about the relationship between bleeding and polyps.
The methodology, quality and population characteristics of the studies also influenced how bleeding was associated with cancer. The association of bleeding with colorectal cancer was higher (RDOR 2.2, 95% CI 1.2 - 4.0) when both symptomatic and asymptomatic people (AUC 0.71), rather than just those with symptoms (AUC 0.59) were included in the population from which patients were recruited. The accuracy of bleeding in diagnosing colorectal cancer was higher when colonoscopy (AUC 0.68), compared to all other diagnostic modalities (AUC 0.63), was used as the reference standard.
Type of bleeding
Few papers provided information about bleeding type (details provided in Additional File 4) [8, 19, 31, 34, 41, 48, 49, 59, 62]. Of these, only bleeding mixed with stool and dark red blood had DORs consistently above 1. For bleeding mixed with stool the summary DOR was 3.1 (95% CI 2.0 - 4.8, p < 0.001), and the AUC 0.68. For dark red blood, the DOR was 3.9 (95% CI 1.7 - 9.2, p < 0.01), and the AUC was 0.71. No DOR and AUC was estimated for bright red bleeding, because this was reported in only 3 papers, for which the odds ratios were 0.9, 1.1 and 1.1 (Additional File 4).
Eighteen papers provided information about the relationship between weight loss and colorectal cancer [8, 18, 19, 22, 25, 26, 32, 34, 35, 37, 47–49, 55, 59, 61–63], and six of these papers [26, 47–49, 61, 63] also provided information about the relationship between weight loss and polyps.
The symptoms usually considered important for colorectal cancer diagnosis are rectal bleeding, change in bowel habit, abdominal pain, weight loss, diarrhoea and constipation. Of these, in our systematic review, only weight loss and rectal bleeding were associated with colorectal cancer, albeit with low DORs and AUCs. There was evidence that the other symptoms were not associated with colorectal cancer. Accuracy did not vary by primary care or specialist setting, or study type, suggesting that our findings are generaliseable across settings.
The lack of clinical usefulness of symptoms is also confirmed by the positive likelihood ratio of the symptoms. To provide strong evidence for ruling in disease, a positive likelihood ratio should be greater than 10 . Faecal occult blood tests have been shown to have positive likelihood ratios of up to 47.39 . Weight loss was the symptom with the highest positive likelihood ratio: 2.5. This means that a person with weight loss has less than a 3-fold increase in colorectal cancer risk. However, weight loss is generally a non-specific symptom, and in most of the studies included in this meta-analysis was analysed in a population already selected for being of sufficiently high risk of colorectal cancer to warrant investigation for colorectal cancer. Apart from weight loss and rectal bleeding, the positive likelihood ratio of other symptoms was around one. Our review also suggests that, even when symptoms are associated with cancer, they are not associated with polyps.
Previous systematic reviews of symptoms also found that clinical features have limited predictive value in identifying patients with cancer [76, 77], although a systematic review of rectal bleeding in combination with other symptoms showed that this had modest diagnostic value . Another review, assessing only those symptoms with a predictive value of > 5%, has also identified that some symptoms may be of some value . Our review is based on a larger number of studies, evaluated both cancer and polyps, applied a more rigorous methodology, using hierarchical summary ROC method that takes into account unexplained heterogeneity between studies, and included assessment of whether study design or population characteristics affected the results.
Quality of studies
Our review showed that most studies had methodological flaws. For example, the reference standard differed between studies and fewer than half the papers used colonoscopy to identify cancer and polyps. We have shown that the studies that used colonoscopy showed a somewhat stronger association between rectal bleeding and cancer (AUC 0.68) than when other methods were used to determine the presence of cancer (AUC 0.63). This is presumably because the association is underestimated when using a poorer reference standard . However, most other measures of study quality were not shown to affect the results. Nevertheless, the quality of studies and their reporting should be improved. For example, we found that in over half the papers there were data discrepancies or miscalculations within the papers. While most of these were minor, 10% required some assumptions to extract the data. Adherence to quality criteria such as the STARD checklist and flow diagram would ensure that the quality of reporting .
Symptom presentation, and their predictive value, may be affected by the patient's age. However, the papers analysed did not present symptom and outcome information in sufficient detail to explore this relationship.
There was also no consistency between studies in the way in which symptoms were elicited or interpreted. Indeed very few studies provided information about how symptoms were elicited and did not characterise them: for example while some studies defined rectal bleeding as the first episode of bleeding or gave a time limit during which the bleeding occurred, the majority of studies provided no definition at all. Similarly, few studies gave definitions for constipation or diarrhoea or differentiated this from change in bowel habit. Also, there is potential for recall bias, with few studies providing information about when the symptoms were elicited in relation to when the diagnosis was made. In some studies symptoms were obtained from medical records, in other studies they were recorded during a consultation. In other studies a specific questionnaire was used, sometimes administered as part of the medical consultation and in others administered either by a researcher specifically for the study, or completed by the patients themselves. To do better studies in the future, a standardised repeatable method of eliciting symptoms is needed and is now available . In practice symptoms are seldom assessed in isolation, and need to be evaluated together as well as with other patient characteristics. Where this has been done, it has been found that some additional symptoms may improve diagnostic value . However, few studies have presented such information, and there is a need for a well conducted primary study to evaluate this.
Our systematic review has shown that, on current evidence, only rectal bleeding and the general symptom of weight loss are associated with colorectal cancer, and may be helpful in selecting patients for further investigation with colonoscopy. Until such time as better studies are done, it seems wise to channel resources for cancer detection towards population based screening programmes using FOBT rather than relying on identifying all cancers and precancerous polyps through investigating people with symptoms.
Barbara-Ann Adelstein, senior research fellow, Prince of Wales Clinical School, Faculty of Medicine, University of NSW, Sydney, Australia
Les Irwig, professor of epidemiology, STEP, School of Public Health, University of Sydney, Australia
Petra Macaskill, associate professor, STEP, School of Public Health, University of Sydney, Australia
Siew F Chan, biostatistician, STEP, School of Public Health, University of Sydney, Australia
Peter H Katelaris, gastroenterologist, Concord Repatriation General Hospital, University of Sydney, Australia
This study was funded by the Australian National Health and Medical Research Council Program, grant 402764. All of the researchers involved in this project are independent of the funding body (Australian National Health and Medical Research Council) and the research had no industry sponsorship. We have not used any professional medical writers.
area under the curve
diagnostic odds ratio
faecal occult blood test
positive likelihood ratio
negative likelihood ratio
receiver operating characteristic
relative receiver operating characteristic
Summary receiver operating characteristic
hierarchical summary receiver operating characteristic
Standards for the reporting of diagnostic accuracy studies
- Cooper N, Westlake S: Cancer incidence and mortality: trends in the United Kingdom and constituent countries, 1993 to 2004. Health Statistics Quarterly. 2008, Summer (38): 33-46.Google Scholar
- Majumdar SR, Fletcher RH, Evans AT: How does colorectal cancer present? Symptoms, duration, and clues to location. Am J Gastroenterol. 1999, 94 (10): 3039-3045. 10.1111/j.1572-0241.1999.01454.x.View ArticlePubMedGoogle Scholar
- Mulcahy HE, O'Donoghue DP: Duration of colorectal cancer symptoms and survival: the effect of confounding clinical and pathological variables. Eur J Cancer. 1997, 33 (9): 1461-1467. 10.1016/S0959-8049(97)00089-0.View ArticlePubMedGoogle Scholar
- Dent OF, Goulston KJ, Zubrzycki J, Chapuis PH: Bowel symptoms in an apparently well population. Dis Colon Rectum. 1986, 29 (4): 243-247. 10.1007/BF02553027.View ArticlePubMedGoogle Scholar
- Goulston K, Chapuis P, Dent O, Bokey L: Significance of bowel symptoms. Med J Aust. 1987, 146 (12): 631-633.PubMedGoogle Scholar
- European Panel on the Appropriateness of Gastrointestinal Endoscopy II (EPAGE). 2008, Lausanne, Switzerland, 2009:
- Dodds S, Dodds A, Vakis S, Flashman K, Senapati A, Cripps N, Thompson M: The value of various factors associated with rectal bleeding in the diagnosis of colorectal cancer. Gut. 1999, 44 (suppl 1): A99-Google Scholar
- Norrelund N, Norrelund H: Colorectal cancer and polyps in patients aged 40 years and over who consult a GP with rectal bleeding. Fam Pract. 1996, 13 (2): 160-165. 10.1093/fampra/13.2.160.View ArticlePubMedGoogle Scholar
- Moses LE, Shapiro D, Littenberg B: Combining independent studies of a diagnostic test into a summary ROC curve: data-analytic approaches and some additional considerations. Stat Med. 1993, 12 (14): 1293-1316. 10.1002/sim.4780121403.View ArticlePubMedGoogle Scholar
- Rutter CM, Gatsonis CA: Regression methods for meta-analysis of diagnostic test data. Acad Radiol. 1995, 2 (Suppl 1): S48-56.PubMedGoogle Scholar
- Rutter CM, Gatsonis CA: A hierarchical regression approach to meta-analysis of diagnostic test accuracy evaluations. Stat Med. 2001, 20 (19): 2865-2884. 10.1002/sim.942.View ArticlePubMedGoogle Scholar
- Macaskill P: Empirical Bayes estimates generated in a hierarchical summary ROC analysis agreed closely with those of a full Bayesian analysis. J Clin Epidemiol. 2004, 57 (9): 925-932. 10.1016/j.jclinepi.2003.12.019.View ArticlePubMedGoogle Scholar
- Adler A, Roll S, Marowski B, Drossel R, Rehs H-U, Willich SN, Riese J, Wiedenmann B, Rosch T: Appropriateness of colonoscopy in the era of colorectal cancer screening: a prospective, multicenter study in a private-practice setting (Berlin Colonoscopy Project 1, BECOP 1). Dis Colon Rectum. 2007, 50 (10): 1628-1638. 10.1007/s10350-007-9029-y.View ArticlePubMedGoogle Scholar
- Ahmed S, Leslie A, Thaha MA, Carey FA, Steele RJ: Lower gastrointestinal symptoms are not predictive of colorectal neoplasia in a faecal occult blood screen-positive population. Br J Surg. 2005, 92 (4): 478-481. 10.1002/bjs.4879.View ArticlePubMedGoogle Scholar
- Bafandeh Y, Khoshbaten M, Eftekhar Sadat A-T, Farhang S: Clinical predictors of colorectal polyps and carcinoma in a low prevalence region: results of a colonoscopy based study. World J Gastroenterol. 2008, 14 (10): 1534-1538. 10.3748/wjg.14.1534.View ArticlePubMedPubMed CentralGoogle Scholar
- Bat L, Pines A, Shemesh E, Levo Y, Zeeli D, Scapa E, Rosenblum Y: Colonoscopy in patients aged 80 years or older and its contribution to the evaluation of rectal bleeding. Postgrad Med J. 1992, 68 (799): 355-358. 10.1136/pgmj.68.799.355.View ArticlePubMedPubMed CentralGoogle Scholar
- Berkowitz I, Kaplan M: Indications for colonoscopy. An analysis based on indications and diagnostic yield. S Afr Med J. 1993, 83 (4): 245-248.PubMedGoogle Scholar
- Bhatti MA, Kashif MA, Imran M: Colonoscopic evaluation of middle aged patients with altered bowel habits. Journal of the College of Physicians and Surgeons - Pakistan. 2004, 14 (8): 481-484.PubMedGoogle Scholar
- Bjerregaard NC, Tottrup A, Sorensen HT, Laurberg S: Diagnostic value of self-reported symptoms in Danish outpatients referred with symptoms consistent with colorectal cancer. Colorectal Dis. 2007, 9 (5): 443-451. 10.1111/j.1463-1318.2006.01170.x.View ArticlePubMedGoogle Scholar
- Brenna E, Skreden K, Waldum HL, Marvik R, Dybdahl JH, Kleveland PM, Sandvik AK, Halvorsen T, Myrvold HE, Petersen H: The benefit of colonoscopy. Scand J Gastroenterol. 1990, 25 (1): 81-88. 10.3109/00365529008999213.View ArticlePubMedGoogle Scholar
- Brewster NT, Grieve DC, Saunders JH: Double-contrast barium enema and flexible sigmoidoscopy for routine colonic investigation. Br J Surg. 1994, 81 (3): 445-447. 10.1002/bjs.1800810341.View ArticlePubMedGoogle Scholar
- Chak A, Post AB, Cooper GS: Clinical variables associated with colorectal cancer on colonoscopy: a prediction model. Am J Gastroenterol. 1996, 91 (12): 2483-2488.PubMedGoogle Scholar
- Charalambopoulos A, Syrigos KN, Ho JL, Murday VA, Leicester RJ: Colonoscopy in symptomatic patients with positive family history of colorectal cancer. Anticancer Res. 2000, 20 (3B): 1991-1994.PubMedGoogle Scholar
- Cheong KL, Roohi S, Jarmin R, Sagap I, Tong SH, Qureshi A: The yield for colorectal cancer and adenoma by indication at colonoscopy. Med J Malaysia. 2000, 55 (4): 464-466.PubMedGoogle Scholar
- Curless R, French J, Williams GV, James OF: Comparison of gastrointestinal symptoms in colorectal carcinoma patients and community controls with respect to age. Gut. 1994, 35 (9): 1267-1270. 10.1136/gut.35.9.1267.View ArticlePubMedPubMed CentralGoogle Scholar
- de Bosset V, Froehlich F, Rey JP, Thorens J, Schneider C, Wietlisbach V, Vader JP, Burnand B, Muhlhaupt B, Fried M, Gonvers JJ: Do explicit appropriateness criteria enhance the diagnostic yield of colonoscopy?. Endoscopy. 2002, 34 (5): 360-368. 10.1055/s-2002-25277.View ArticlePubMedGoogle Scholar
- Douek M, Wickramasinghe M, Clifton MA: Does isolated rectal bleeding suggest colorectal cancer?. Lancet. 1999, 354 (9176): 393-View ArticlePubMedGoogle Scholar
- du Toit J, Hamilton W, Barraclough K: Risk in primary care of colorectal cancer from new onset rectal bleeding: 10 year prospective study. BMJ. 2006, 333 (7558): 69-70. 10.1136/bmj.38846.684850.2F.View ArticlePubMedPubMed CentralGoogle Scholar
- Dukas L, Willett WC, Colditz GA, Fuchs CS, Rosner B, Giovannucci EL: Prospective study of bowel movement, laxative use, and risk of colorectal cancer among women. Am J Epidemiol. 2000, 151 (10): 958-964.View ArticlePubMedGoogle Scholar
- Duncan JE, Sweeney WB, Trudel JL, Madoff RD, Mellgren AF, Duncan JE, Sweeney WB, Trudel JL, Madoff RD, Mellgren AF: Colonoscopy in the elderly: low risk, low yield in asymptomatic patients. Dis Colon Rectum. 2006, 49 (5): 646-651. 10.1007/s10350-005-0306-3.View ArticlePubMedGoogle Scholar
- Ellis BG, Thompson MR: Factors identifying higher risk rectal bleeding in general practice. Br J Gen Pract. 2005, 55 (521): 949-955.PubMedPubMed CentralGoogle Scholar
- Farrands PA, Hardcastle JD: Colorectal screening by a self-completion questionnaire. Gut. 1984, 25 (5): 445-447. 10.1136/gut.25.5.445.View ArticlePubMedPubMed CentralGoogle Scholar
- Ferraris R, Senore C, Fracchia M, Sciallero S, Bonelli L, Atkin WS, Segnan N, Score Working Group I: Predictive value of rectal bleeding for distal colonic neoplastic lesions in a screened population. Eur J Cancer. 2004, 40 (2): 245-252. 10.1016/j.ejca.2003.08.002.View ArticlePubMedGoogle Scholar
- Fijten GH, Starmans R, Muris JW, Schouten HJ, Blijham GH, Knottnerus JA: Predictive value of signs and symptoms for colorectal cancer in patients with rectal bleeding in general practice. Fam Pract. 1995, 12 (3): 279-286. 10.1093/fampra/12.3.279.View ArticlePubMedGoogle Scholar
- Fontagnier EM, Manegold BC: [Colonoscopy in patients over 80 years of age. Indications, methods and results]. Dtsch Med Wochenschr. 2000, 125 (44): 1319-1322. 10.1055/s-2000-8078.View ArticlePubMedGoogle Scholar
- Haenszel W, Berg JW, Segi M, Kurihara M, Locke FB: Large-bowel cancer in Hawaiian Japanese. J Natl Cancer Inst. 1973, 51 (6): 1765-1779.PubMedGoogle Scholar
- Hamilton W, Round A, Sharp D, Peters TJ: Clinical features of colorectal cancer before diagnosis: a population-based case-control study. Br J Cancer. 2005, 93 (4): 399-405. 10.1038/sj.bjc.6602714.View ArticlePubMedPubMed CentralGoogle Scholar
- Higginson J: Etiological factors in gastrointestinal cancer in man. J Natl Cancer Inst. 1966, 37 (4): 527-545.PubMedGoogle Scholar
- Jacobs EJ, White E: Constipation, laxative use, and colon cancer among middle-aged adults. Epidemiology. 1998, 9 (4): 385-391. 10.1097/00001648-199807000-00007.View ArticlePubMedGoogle Scholar
- Jain M, Cook GM, Davis FG, Grace MG, Howe GR, Miller AB: A case-control study of diet and colorectal cancer. Int J Cancer. 1980, 26 (6): 757-768. 10.1002/ijc.2910260609.View ArticlePubMedGoogle Scholar
- Jensen J, Kewenter J, Swedenborg J: The correlation of symptoms, occult blood tests, and neoplasms in patients referred for double-contrast barium enema. Scand J Gastroenterol. 1993, 28 (10): 911-914. 10.3109/00365529309103134.View ArticlePubMedGoogle Scholar
- Kassa E: Colonoscopy in the investigation of colonic diseases. East Afr Med J. 1996, 73 (11): 741-745.PubMedGoogle Scholar
- Kojima M, Wakai K, Tokudome S, Tamakoshi K, Toyoshima H, Watanabe Y, Hayakawa N, Suzuki K, Hashimoto S, Ito Y, Tamakoshi A: Bowel movement frequency and risk of colorectal cancer in a large cohort study of Japanese men and women. Br J Cancer. 2004, 90 (7): 1397-1401. 10.1038/sj.bjc.6601735.View ArticlePubMedPubMed CentralGoogle Scholar
- Kune GA, Kune S, Field B, Watson LF: The role of chronic constipation, diarrhea, and laxative use in the etiology of large-bowel cancer. Data from the Melbourne Colorectal Cancer Study. Dis Colon Rectum. 1988, 31 (7): 507-512. 10.1007/BF02553722.View ArticlePubMedGoogle Scholar
- Lee JF-Y, Ng SS-M, Yiu RY-C, Leung K-L, Lau JW-Y: Colonoscopy in adult patients: A review of tis indications and its yield in detecting colorectal neoplasia. Annals of the College of Surgeons (Hong Kong). 2002, 6: 48-52. 10.1046/j.1442-2034.2002.00130.x.View ArticleGoogle Scholar
- Leis VM, Hughes ML, Williams CB, Nuemaster TD, Ludwig DJ, Fontenelle LJ: Risk factors predictive of positive finding at colonoscopy. Curr Surg. 2001, 58: 227-229. 10.1016/S0149-7944(00)00453-0.View ArticlePubMedGoogle Scholar
- Leung WK, Ho KY, Kim W-h, Lau JYW, Ong E, Hilmi I, Kullavanijaya P, Wang C-y, Li C-j, Fujita R, Abdullah M, Tandon R, Sung JJY: Colorectal neoplasia in Asia: a multicenter colonoscopy survey in symptomatic patients. Gastrointest Endosc. 2006, 64 (5): 751-759. 10.1016/j.gie.2006.06.082.View ArticlePubMedGoogle Scholar
- Mant A, Bokey EL, Chapuis PH, Killingback M, Hughes W, Koorey SG, Cook I, Goulston KJ, Dent OF: Rectal bleeding. Do other symptoms aid in diagnosis?. Dis Colon Rectum. 1989, 32 (3): 191-196. 10.1007/BF02554525.View ArticlePubMedGoogle Scholar
- Metcalf JV, Smith J, Jones R, Record CO: Incidence and causes of rectal bleeding in general practice as detected by colonoscopy. Br J Gen Pract. 1996, 46 (404): 161-164.PubMedPubMed CentralGoogle Scholar
- Morini S, Hassan C, Meucci G, Toldi A, Zullo A, Minoli G: Diagnostic yield of open access colonoscopy according to appropriateness. Gastrointest Endosc. 2001, 54 (2): 175-179. 10.1067/mge.2001.116565.View ArticlePubMedGoogle Scholar
- Nakama H, Zhang B, Fattah A, Kamijo N, Fukazawa K: Relationships between a sign of rectal bleeding and the results of an immunochemical occult blood test, and colorectal cancer. Eur J Cancer Prev. 2000, 9 (5): 325-328. 10.1097/00008469-200010000-00006.View ArticlePubMedGoogle Scholar
- Nakamura GJ, Schneiderman LJ, Klauber MR: Colorectal cancer and bowel habits. Cancer. 1984, 54 (7): 1475-1477. 10.1002/1097-0142(19841001)54:7<1475::AID-CNCR2820540743>3.0.CO;2-M.View ArticlePubMedGoogle Scholar
- Nascimbeni R, Donato F, Ghirardi M, Mariani P, Villanacci V, Salerni B: Constipation, anthranoid laxatives, melanosis coli, and colon cancer: a risk assessment using aberrant crypt foci. Cancer Epidemiol Biomarkers Prev. 2002, 11 (8): 753-757.PubMedGoogle Scholar
- Neugut AI, Garbowski GC, Waye JD, Forde KA, Treat MR, Tsai JL, Lee WC: Diagnostic yield of colorectal neoplasia with colonoscopy for abdominal pain, change in bowel habits, and rectal bleeding. Am J Gastroenterol. 1993, 88 (8): 1179-1183.PubMedGoogle Scholar
- Panzuto F, Chiriatti A, Bevilacqua S, Giovannetti P, Russo G, Impinna S, Pistilli F, Capurso G, Annibale B, Delle Fave G: Symptom-based approach to colorectal cancer: survey of primary care physicians in Italy. Dig Liver Dis. 2003, 35 (12): 869-875. 10.1016/j.dld.2003.07.005.View ArticlePubMedGoogle Scholar
- Park Y, Freedman AN, Gail MH, Pee D, Hollenbeck A, Schatzkin A, Pfeiffer RM: Validation of a colorectal cancer risk prediction model among white patients age 50 years and older. J Clin Oncol. 2009, 27 (5): 694-698. 10.1200/JCO.2008.17.4813.View ArticlePubMedGoogle Scholar
- Pernu J: An epidemiological study of the digestive organs and respiratory system. Annales Medicinae Internae Fenniae Supplementum. 1960, 49 (supp 33): 1-117.PubMedGoogle Scholar
- Roberts MC, Millikan RC, Galanko JA, Martin C, Sandler RS: Constipation, laxative use, and colon cancer in a North Carolina population. Am J Gastroenterol. 2003, 98 (4): 857-864. 10.1111/j.1572-0241.2003.07386.x.View ArticlePubMedGoogle Scholar
- Robertson R, Campbell C, Weller DP, Elton R, Mant D, Primrose J, Nugent K, Macleod U, Sharma R: Predicting colorectal cancer risk in patients with rectal bleeding. Br J Gen Pract. 2006, 56 (531): 763-767.PubMedPubMed CentralGoogle Scholar
- Sardinha TC, Nogueras JJ, Ehrenpreis ED, Zeitman D, Estevez V, Weiss EG, Wexner SD: Colonoscopy in octogenarians: a review of 428 cases. Int J Colorectal Dis. 1999, 14 (3): 172-176. 10.1007/s003840050205.View ArticlePubMedGoogle Scholar
- Schoepfer A, Marbet UA: Colonoscopic findings of symptomatic patients aged 50 to 80 years suggest that work-up of tumour suspicious symptoms hardly reduces cancer-induced mortality. Swiss Med Wkly. 2005, 135 (45-46): 679-683.PubMedGoogle Scholar
- Selvachandran SN, Hodder RJ, Ballal MS, Jones P, Cade D: Prediction of colorectal cancer by a patient consultation questionnaire and scoring system: a prospective study. Lancet. 2002, 360 (9329): 278-283. 10.1016/S0140-6736(02)09549-1.View ArticlePubMedGoogle Scholar
- Steine S, Stordahl A, Laerum F, Laerum E: Referrals for double-contrast barium examination. Factors influencing the probability of finding polyps or cancer. Scand J Gastroenterol. 1994, 29 (3): 260-264. 10.3109/00365529409090474.View ArticlePubMedGoogle Scholar
- Tan YM, Rosmawati M, Ranjeev P, Goh KL: Predictive factors by multivariate analysis for colorectal cancer in Malaysian patients undergoing colonoscopy. J Gastroenterol Hepatol. 2002, 17 (3): 281-284. 10.1046/j.1440-1746.2002.02694.x.View ArticlePubMedGoogle Scholar
- Tate JJ, Royle GT: Open access colonoscopy for suspected colonic neoplasia. Gut. 1988, 29 (10): 1322-1325. 10.1136/gut.29.10.1322.View ArticlePubMedPubMed CentralGoogle Scholar
- Thompson MR, Perera R, Senapati A, Dodds S: Predictive value of common symptom combinations in diagnosing colorectal cancer. Br J Surg. 2007, 94 (10): 1260-1265. 10.1002/bjs.5826.View ArticlePubMedGoogle Scholar
- Vobecky J, Caro J, Devroede G: A case-control study of risk factors for large bowel carcinoma. Cancer. 1983, 51 (10): 1958-1963. 10.1002/1097-0142(19830515)51:10<1958::AID-CNCR2820511036>3.0.CO;2-W.View ArticlePubMedGoogle Scholar
- Watanabe T, Nakaya N, Kurashima K, Kuriyama S, Tsubono Y, Tsuji I: Constipation, laxative use and risk of colorectal cancer: The Miyagi Cohort Study. Eur J Cancer. 2004, 40 (14): 2109-2115. 10.1016/j.ejca.2004.06.014.View ArticlePubMedGoogle Scholar
- Wauters H, Van Casteren V, Buntinx F: Rectal bleeding and colorectal cancer in general practice: diagnostic study. BMJ. 2000, 321 (7267): 998-999. 10.1136/bmj.321.7267.998.View ArticlePubMedPubMed CentralGoogle Scholar
- Wynder EL, Kajitani T, Ishikawa S, Dodo H, Takano A: Environmental factors of cancer of the colon and rectum. II. Japanese epidemiological data. Cancer. 1969, 23 (5): 1210-1220. 10.1002/1097-0142(196905)23:5<1210::AID-CNCR2820230530>3.0.CO;2-M.View ArticlePubMedGoogle Scholar
- Wynder EL, Shigematsu T: Environmental factors of cancer of the colon and rectum. Cancer. 1967, 20 (9): 1520-1561. 10.1002/1097-0142(196709)20:9<1520::AID-CNCR2820200920>3.0.CO;2-3.View ArticlePubMedGoogle Scholar
- Zbar AP, Pignatelli M, Sherman D, Toomey P, Kmiot WA: An analysis of site-specific attributable pathologies for colorectal symptoms: diagnostic yield of colonoscopy. Colorectal Dis. 1988, 1:Google Scholar
- Zerey M, Paton BL, Khan PD, Lincourt AE, Kercher KW, Greene FL, Heniford BT: Colonoscopy in the very elderly: a review of 157 cases. Surg Endosc. 2007, 21 (10): 1806-1809. 10.1007/s00464-007-9269-x.View ArticlePubMedGoogle Scholar
- Deeks JJ, Altman DG: Diagnostic tests 4: likelihood ratios. BMJ. 2004, 329 (7458): 168-169. 10.1136/bmj.329.7458.168.View ArticlePubMedPubMed CentralGoogle Scholar
- Soares-Weiser K, Burch J, St John J, Smith S, Westwood M, Kleijnen J: Diagnostic accuracy and cost-effectiveness of faecal occult blood tests used in screening for colorectal cancer: A systematic review. 2007, York: Centre for Reviews and DisseminationGoogle Scholar
- Ford AC, Veldhuyzen van Zanten SJ, Rodgers CC, Talley NJ, Vakil NB, Moayyedi P, Veldhuyzen van Zanten SJO: Diagnostic utility of alarm features for colorectal cancer: systematic review and meta-analysis. Gut. 2008, 57 (11): 1545-1553. 10.1136/gut.2008.159723.View ArticlePubMedGoogle Scholar
- Jellema P, van der Windt DAWM, Bruinvels DJ, Mallen CD, van Weyenberg SJB, Mulder CJ, de Vet HCW: Value of symptoms and additional diagnostic tests for colorectal cancer in primary care: systematic review and meta-analysis. BMJ. 2010, 340: c1269-10.1136/bmj.c1269.View ArticlePubMedPubMed CentralGoogle Scholar
- Olde Bekkink M, McCowan C, Falk GA, Teljeur C, Van de Laar FA, Fahey T: Diagnostic accuracy systematic review of rectal bleeding in combination with other symptoms, signs and tests in relation to colorectal cancer. Br J Cancer. 2010, 102 (1): 48-58. 10.1038/sj.bjc.6605426.View ArticlePubMedGoogle Scholar
- Shapley M, Mansell G, Jordan JL, Jordan KP: Positive predictive values of >= 5% in primary care for cancer: systematic review. Br J Gen Pract. 2010, 60 (578): e366-377. 10.3399/bjgp10X515412.View ArticlePubMedPubMed CentralGoogle Scholar
- Buck A, Gart J: Comparison of a screening test and a reference test in epidemiologic studies. I. Indices of agreement and their relation to prevalence. American Journal of Epidemiology. 1966, 83 (3): 586-592.PubMedGoogle Scholar
- Bossuyt PM, Reitsma JB, Bruns DE, Gatsonis CA, Glasziou PP, Irwig LM, Lijmer JG, Moher D, Rennie D, de Vet HCW: Towards complete and accurate reporting of studies of diagnostic accuracy: the STARD initiative. BMJ. 2003, 326 (7379): 41-44. 10.1136/bmj.326.7379.41.View ArticlePubMedPubMed CentralGoogle Scholar
- Adelstein B-A, Irwig L, Macaskill P, Katelaris PH, Jones DB, Bokey L: A self administered reliable questionnaire to assess lower bowel symptoms. BMC Gastroenterol. 2008, 8: 8-10.1186/1471-230X-8-8.View ArticlePubMedPubMed CentralGoogle Scholar
- The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-230X/11/65/prepub
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